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Using the pressure and flow signals measured at the mouth, the model\u2019s quadratic pressure\u2013volume (P\u2013V) characteristic is fit to these data in each respiratory cycle by appropriate estimates of the model parameters. Parameter changes during ventilation can thus also be detected. The algorithm is first refined and assessed using data derived from simulated patients represented through a sigmoidal P\u2013V characteristic with hysteresis. As satisfactory results are achieved with the simulated data, the algorithm is evaluated with real data obtained from actual patients undergoing assisted ventilation. The proposed nonlinear dynamic model and associated parameter estimation algorithm yield closer fits than the static linear models computed by respiratory machines, with only a minor increase in computation. They also provide more information to the physician, such as the pressure\u2013volume (P\u2013V) curvature and the condition of the lung (whether normal, under-inflated, or over-inflated). This information can be used to provide safer ventilation for patients, for instance by ventilating them in the linear region of the respiratory system.<\/jats:p>","DOI":"10.1177\/00375497241255149","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T02:50:25Z","timestamp":1718938225000},"page":"1071-1083","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nonlinear identification algorithm for online and offline study of pulmonary mechanical ventilation"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2580-8837","authenticated-orcid":false,"given":"Diego A","family":"Riva","sequence":"first","affiliation":[{"name":"Instituto LEICI, UNLP-CONICET, Facultad de Ingenier\u00eda, Universidad Nacional de La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina A","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Instituto LEICI, UNLP-CONICET, Facultad de Ingenier\u00eda, Universidad Nacional de La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F","family":"Puleston","sequence":"additional","affiliation":[{"name":"Instituto LEICI, UNLP-CONICET, Facultad de Ingenier\u00eda, Universidad Nacional de La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Corsiglia","sequence":"additional","affiliation":[{"name":"Hospital I.E.A y C. San Juan de Dios de La Plata, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahuel","family":"Dargains","sequence":"additional","affiliation":[{"name":"Hospital I.E.A y C. 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