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To address this knowledge gap, we conducted a cross-sectional study with 956 adolescents. Participants were disadvantaged in social class. Tobacco use included lifetime and past month use of combustible tobacco and nicotine vaping. Social class discrimination included multiple sources, such as teachers, classmates, teenagers, friends, and community members. Latent profile analyses revealed four subgroups of adolescents with experiences of social class discrimination: Frequent, Infrequent, Out-of-School, and In-School. Adolescents in the Frequent and Out-of-School subgroups used the most tobacco products, whereas adolescents in the In-School and Infrequent subgroups used the least tobacco products. Race\/ethnicity and gender were associated with subgroup membership. Findings highlight the need for social class discrimination interventions.<\/jats:p>","DOI":"10.1177\/0044118x251406595","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:44:08Z","timestamp":1767955448000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Settings Matter: Examining the Association Between Social Class Discrimination in and Out-of-School, Tobacco Use, and Nicotine Vaping Among Adolescents"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-9801","authenticated-orcid":false,"given":"Zena R.","family":"Mello","sequence":"first","affiliation":[{"name":"San Francisco State University, CA, USA"},{"name":"The University of the Pacific, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-0387","authenticated-orcid":false,"given":"Christine R.","family":"Starr","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-014X","authenticated-orcid":false,"given":"Vani","family":"Kakar","sequence":"additional","affiliation":[{"name":"San Francisco State University, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3460-2892","authenticated-orcid":false,"given":"Adam","family":"Suri","sequence":"additional","affiliation":[{"name":"San Francisco State University, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4222-9209","authenticated-orcid":false,"given":"Manuel","family":"Abundis-Morales","sequence":"additional","affiliation":[{"name":"San Francisco State University, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9141-0815","authenticated-orcid":false,"given":"Busra","family":"Dogru","sequence":"additional","affiliation":[{"name":"San Francisco State University, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Ahuja M. 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