{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:46:26Z","timestamp":1792737986222,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009933","name":"ethicon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009933","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["INQUIRY"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    The burden of complications associated with peripheral intravenous use is underevaluated, in part, due to the broad use, inconsistent coding, and lack of mandatory reporting of these devices. This study aimed to analyze the clinical and economic impact of peripheral intravenous\u2013related complications on hospitalized patients. This analysis of Premier Perspective\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Database US hospital discharge records included admissions occurring between July 1, 2013 and June 30, 2015 for pneumonia, chronic obstructive pulmonary disease, myocardial infarction, congestive heart failure, chronic kidney disease, diabetes with complications, and major trauma (hip, spinal, cranial fractures). Admissions were assumed to include a peripheral intravenous. Admissions involving surgery, dialysis, or central venous lines were excluded. Multivariable analyses compared inpatient length of stay, cost, admission to intensive care unit, and discharge status of patients with versus without peripheral intravenous\u2013related complications (bloodstream infection, cellulitis, thrombophlebitis, other infection, or extravasation). Models were conducted separately for congestive heart failure, chronic obstructive pulmonary disease, diabetes with complications, and overall (all 7 diagnoses) and adjusted for demographics, comorbidities, and hospital characteristics. We identified 588\u2009375 qualifying admissions: mean (SD), age 66.1 (20.6) years; 52.4% female; and 95.2% urgent\/emergent admissions. Overall, 1.76% of patients (n = 10\u2009354) had peripheral intravenous\u2013related complications. In adjusted analyses between patients with versus without peripheral intravenous complications, the mean (95% confidence interval) inpatient length of stay was 5.9 (5.8-6.0) days versus 3.9 (3.9-3.9) days; mean hospitalization cost was $10\u2009895 ($10\u2009738-$11\u2009052) versus $7009 ($6988-$7031). Patients with complications were less likely to be discharged home versus those without (62.4% [58.6%-66.1%] vs 77.6% [74.6%-80.5%]) and were more likely to have died (3.6% [2.9%-4.2%] vs 0.7% [0.6%-0.9%]). Models restricted to single admitting diagnosis were consistent with overall results. Patients with peripheral intravenous\u2013related complications have longer length of stay, higher costs, and greater risk of death than patients without such complications; this is true across diagnosis groups of interest. Future research should focus on reducing these complications to improve clinical and economic outcomes.\n                  <\/jats:p>","DOI":"10.1177\/0046958019875562","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T01:49:50Z","timestamp":1568598590000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Increased Clinical and Economic Burden Associated With Peripheral Intravenous Catheter\u2013Related Complications: Analysis of a US Hospital Discharge Database"],"prefix":"10.1177","volume":"56","author":[{"given":"Sangtaeck","family":"Lim","sequence":"first","affiliation":[{"name":"Ethicon, Inc., Somerville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Gangoli","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Medical Devices Companies, Somerville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Adams","sequence":"additional","affiliation":[{"name":"Ethicon, Inc., Somerville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hyde","sequence":"additional","affiliation":[{"name":"Ethicon, Inc., Somerville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Broder","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Chang","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila R.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-4682","authenticated-orcid":false,"given":"Marian H.","family":"Tarbox","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Bentley","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Ovington","sequence":"additional","affiliation":[{"name":"Ethicon, Inc., Somerville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Walt","family":"Danker","sequence":"additional","affiliation":[{"name":"Ethicon, Inc., Somerville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,15]]},"reference":[{"key":"bibr1-0046958019875562","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.164940"},{"key":"bibr2-0046958019875562","doi-asserted-by":"publisher","DOI":"10.4065\/81.9.1159"},{"key":"bibr3-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(09)70565-5"},{"key":"bibr4-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61082-4"},{"key":"bibr5-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007798.pub2"},{"key":"bibr6-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2536-0"},{"key":"bibr7-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.04.035"},{"key":"bibr8-0046958019875562","unstructured":"Bullard KM, Dunn DL. Bloodstream and intravascular catheter infections. In: Holzheimer RG, Mannick JA, eds. Surgical Treatment: Evidence-Based and Problem-Oriented. Munich, Germany: Zuckschwerdt; 2001. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK7008\/"},{"key":"bibr9-0046958019875562","unstructured":"National and State Healthcare Associated Infections\u2014Progress Report. Atlanta, GA: Centers for Disease Control and Prevention; March 2016:1-141."},{"key":"bibr10-0046958019875562","volume-title":"The Direct Medical Costs of Healthcare-Associated Infections in U.S. Hospitals and the Benefits of Prevention","author":"R. Douglas Scott II","year":"2009"},{"key":"bibr11-0046958019875562","first-page":"2421","volume-title":"APIC Text of Infection Control and Epidemiology","volume":"1","author":"Crnich C","year":"2005","edition":"2"},{"key":"bibr12-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1086\/497833"},{"key":"bibr13-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510440058033"},{"key":"bibr14-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1590\/1982-0194201500087"},{"key":"bibr15-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2007.06.017"},{"key":"bibr16-0046958019875562","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.11699"},{"key":"bibr17-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.03.003"},{"key":"bibr18-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1086\/660099"},{"key":"bibr19-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1086\/320001"},{"key":"bibr20-0046958019875562","doi-asserted-by":"publisher","DOI":"10.1086\/676533"},{"key":"bibr21-0046958019875562","unstructured":"Premier Applied Sciences\u00ae. Premier Healthcare Database: Data That Informs and Performs. Charlotte, NC: Premier Inc.; 2018. https:\/\/learn.premierinc.com\/white-papers\/premier-healthcare-database-whitepaper. Accessed December 3, 2018."},{"key":"bibr22-0046958019875562","unstructured":"Agency for Healthcare Research and Quality. HCUP Chronic Condition Indicator. Healthcare Cost and Utilization Project (HCUP). www.hcup-us.ahrq.gov\/toolssoftware\/chronic\/chronic.jsp. Published June 2015. 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