{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:02:26Z","timestamp":1784732546211,"version":"3.55.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["No. 2019YFA0112100"],"award-info":[{"award-number":["No. 2019YFA0112100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["INQUIRY"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Paget\u2019s disease of bone (PDB) has long been studied as a condition characterized by disordered bone remodeling. In recent decades, research has increasingly incorporated molecular, genetic, and systemic perspectives, reflecting a broader understanding of the disease. Despite this apparent expansion, changes in the overall research orientation of the PDB field have not been systematically assessed at the field level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A bibliometric analysis was performed using PDB-related publications indexed in the Web of Science Core Collection between 1999 and 2025. Publication trends, keyword-based thematic mapping, temporal patterns, and citation indicators were analyzed to examine shifts in research focus. Studies were categorized into three research orientations. These included bone-centered studies, molecular and genetic studies, and systemic and neurological studies. The evolution of these orientations over time was evaluated using descriptive metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 963 articles published between 1999 and 2025 were included. The Systemic Orientation Index showed a sustained upward trajectory, indicating a gradual shift of PDB research beyond a predominantly bone-centered framework. In time-adjusted citation analysis, systemic and neurological studies showed the highest mean citations per year at 2.63, compared with 1.46 for both bone-centered and molecular and genetic studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings demonstrate a progressive broadening of PDB research beyond a predominantly skeletal framework. While bone-centered studies continue to form the foundation of the field, molecular, genetic, and systemic approaches are playing an important role in shaping contemporary research on PDB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00469580261469861","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:58:13Z","timestamp":1784552293000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changing Research Orientations in Paget\u2019s Disease of Bone: A Bibliometric Analysis"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7408-6497","authenticated-orcid":false,"given":"Lei","family":"Ha","sequence":"first","affiliation":[{"name":"Xiangya Hospital"},{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xiangya Hospital"},{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Xiangya Hospital"},{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1131182"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470724187.ch11"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.05.005"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes13060963"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115633"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0269-0"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.932065"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128984"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71601"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/asi.21062"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joi.2017.08.007"},{"key":"e_1_3_6_14_2","unstructured":"Van Eck NJ Waltman L. Text mining and visualization using VOSviewer. arXiv preprint arXiv:1109.2058. 2011"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307513100"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7079.497"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1108\/00220410810844150"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1204713"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115265"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn266"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1332"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.22.2735"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9599-0"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.845"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001862"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.04.007"},{"key":"e_1_3_6_27_2","first-page":"1000168","article-title":"Disease-specific induced pluripotent stem cell modeling: insights into the pathophysiology of valosin containing protein (VCP) disease","volume":"4","author":"Dec E","year":"2014","unstructured":"Dec E, Ferguson D, Nalbandian A, et al. Disease-specific induced pluripotent stem cell modeling: insights into the pathophysiology of valosin containing protein (VCP) disease. Journal of Stem Cell Research & Therapy. 2014;4:1000168.","journal-title":"Journal of Stem Cell Research & Therapy"}],"container-title":["INQUIRY: The Journal of Health Care Organization, Provision, and Financing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00469580261469861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00469580261469861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00469580261469861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:16:42Z","timestamp":1784729802000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00469580261469861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":26,"alternative-id":["10.1177\/00469580261469861"],"URL":"https:\/\/doi.org\/10.1177\/00469580261469861","relation":{},"ISSN":["0046-9580","1945-7243"],"issn-type":[{"value":"0046-9580","type":"print"},{"value":"1945-7243","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"00469580261469861"}}