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This study evaluated the magnitude and duration of impairment following acute cannabis use. Twenty-eight adult users completed baseline and follow-up assessments at 1, 6, and 12\u2005h after smoking a standardized cannabis cigarette. Measures included subjective intoxication, vital signs, psychomotor performance, muscle strength, balance, and endurance. Blood \u03949-tetrahydrocannabinol (THC) concentrations peaked at one hour and declined by six hours (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while Carboxy-THC showed minimal temporal variation (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.005). Cannabis use significantly increased systolic blood pressure and heart rate, elevated muscle force variability, reduced the rate of force development, and impaired balance and endurance for up to 12\u2005h. 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