{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:00:35Z","timestamp":1777906835276,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>Clinical trials of the effects of ivermectin on onchocercal skin disease have documented reduction in itching, but a less than clear benefit on reactive skin lesions. It has been suggested that one of the positive effects might be the prevention of new lesions. A study among a rural adult farming population in southwestern Nigeria provided ivermectin in three treatment groups and a placebo to community members who were examined and treated at 3-monthly intervals over a 15-month period. Among the 1206 people recruited for the study, 627 (52%) had no lesions at baseline examination. A total of 291 participants without baseline lesions attended all five follow-up examinations, and only their results were analysed. Members of all four groups developed new lesions, but those receiving ivermectin had a consistently lower proportion of lesions than the placebo group. This difference reached statistical significance at the 5% level in three of the five periods and was below the 10% level at the other two periods. These findings are suggestive of an inhibiting effect of ivermectin among those without lesions at the beginning of a community treatment programme, and justify community treatment as a way of limiting morbidity and social stigma associated with these lesions.<\/jats:p>","DOI":"10.1177\/004947550103100214","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:52:03Z","timestamp":1484322723000},"page":"96-98","source":"Crossref","is-referenced-by-count":4,"title":["Development of Reactive Onchocercal Skin Lesions during a Placebo-Controlled Trial with Ivermectin among Persons without Lesions at Baseline"],"prefix":"10.1177","volume":"31","author":[{"given":"William R","family":"Brieger","sequence":"first","affiliation":[{"name":"Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oladele O","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O Olukayode","family":"Ososanya","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"bibr1-004947550103100214","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.9"},{"key":"bibr2-004947550103100214","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218502"},{"key":"bibr3-004947550103100214","first-page":"63","volume":"53","author":"Boussinesq M","year":"1995","journal-title":"Am J Trop Med Hygiene"},{"key":"bibr4-004947550103100214","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90099-3"},{"key":"bibr5-004947550103100214","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1998.00339.x"},{"key":"bibr6-004947550103100214","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90309-Z"},{"key":"bibr7-004947550103100214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.1996.tb00111.x"},{"key":"bibr8-004947550103100214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb11844.x"},{"key":"bibr9-004947550103100214","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.52-270"},{"key":"bibr10-004947550103100214","first-page":"667","volume":"57","author":"Henson PM","year":"1979","journal-title":"Bull World Health Organ"},{"key":"bibr11-004947550103100214","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.54.600"},{"key":"bibr12-004947550103100214","unstructured":"African Programme for Onchocerciasis Control. Community-Directed Treatment with Ivermectin: a Practical Guide for Trainers. 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