{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:00:56Z","timestamp":1777906856095,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Forty-six patients who fulfilled the Duke's clinical diagnostic criteria for infective endocarditis (IE) were evaluated. Thirty-five (76%) patients were below 40 years of age with rheumatic heart disease being the most common underlying heart lesion affecting 26 (56%). An obvious predisposing cardiac lesion could not be ascertained in 22%. Blood culture positivity was 44% with streptococcus heading the list. The incidence of the staphylococcal (25%) and Gram negative bacillary endocarditis (15%) were found to be increasing. Streptococci were susceptible to penicillin with minimum bactericidal concentration:minimum inhibitory concentration within acceptable limits. However, the appearance of methicillin resistant staphylococcus aureus and high level gentamicin resistant enterococcus as aetiological agents of infective endocarditis were found to add to the complexity of the problem. With the emergence of drug-resistant organisms as causative agents of IE, whenever medical therapy is the primary method of treatment of this condition, the selection of antibiotics should depend upon extensive in vitro testing and in vivo monitoring of clinical efficacy.<\/jats:p>","DOI":"10.1177\/004947550203200208","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T11:28:35Z","timestamp":1484306915000},"page":"83-85","source":"Crossref","is-referenced-by-count":16,"title":["Infective Endocarditis: Report of a Prospective Study in an Indian Hospital"],"prefix":"10.1177","volume":"32","author":[{"given":"B","family":"Khanal","sequence":"first","affiliation":[{"name":"Department of Microbiology, BP Koirala Institute of Health Sciences, Dharan, Nepal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B N","family":"Harish","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K R","family":"Sethuraman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"bibr1-004947550203200208","first-page":"2205","volume-title":"The Heart","author":"Durack DT","year":"1998","edition":"9"},{"key":"bibr2-004947550203200208","first-page":"740","volume-title":"Principles and Practice of Infectious Diseases","author":"Scheld WM","year":"1995","edition":"4"},{"key":"bibr3-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.11.945"},{"key":"bibr4-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.57.3.211"},{"key":"bibr5-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.3.313"},{"key":"bibr6-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199303000-00003"},{"key":"bibr7-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.2.276"},{"key":"bibr8-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90143-0"},{"key":"bibr9-004947550203200208","volume-title":"Manual of Clinical Microbiology","author":"Murray PR","year":"1995","edition":"6"},{"key":"bibr10-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90299-E"},{"key":"bibr11-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90422-9"},{"key":"bibr12-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.50.6.506"},{"key":"bibr13-004947550203200208","first-page":"145","volume":"57","author":"Geraci JE","year":"1982","journal-title":"Mayo Clin Proc"},{"key":"bibr14-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.4.608"},{"key":"bibr15-004947550203200208","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/16.suppl_B.84"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/004947550203200208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/004947550203200208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:25:51Z","timestamp":1777641951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/004947550203200208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1177\/004947550203200208"],"URL":"https:\/\/doi.org\/10.1177\/004947550203200208","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}