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This can be delivered with few resources and by non-specialist medical personnel. Reduction in case fatality can only come through the wider appreciation of the need for and application of supportive therapies to treat the life-threatening complications. Hypovolaemia has emerged as a common feature of children presenting with severe malaria complicated by acidosis. Early recognition and prompt treatment may lead to improvements in outcome. We discuss the new evidence supporting the role of hypovolaemia in severe malaria and potential treatment options whilst awaiting the results of clinical trials.<\/jats:p>","DOI":"10.1177\/004947550403400203","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T18:19:14Z","timestamp":1484504354000},"page":"67-70","source":"Crossref","is-referenced-by-count":7,"title":["Fluid Management of Severefalciparum Malaria in African Children"],"prefix":"10.1177","volume":"34","author":[{"given":"Allan","family":"Pamba","sequence":"first","affiliation":[{"name":"The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute (KEMRI)\/WellcomeTrust Unit, Kenya PO Box 230, Kilifi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Maitland","sequence":"additional","affiliation":[{"name":"The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute (KEMRI)\/WellcomeTrust Unit, Kenya PO Box 230, Kilifi, Kenya"},{"name":"Department of Paediatrics, Faculty of Medicine, Imperial College, London"},{"name":"WellcomeTrust Centre for ClinicalTropical Medicine, Imperial College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,4,1]]},"reference":[{"key":"bibr1-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00008-4"},{"key":"bibr2-004947550403400203","volume-title":"Management Of The Child With A Serious Infection Or Severe Malnutrition","author":"WHO","year":"2000"},{"key":"bibr3-004947550403400203","volume-title":"Pediatric Advanced Life Support 1997\u20131999: Emergency Cardiovascular Care Programs","author":"AHA","year":"1997"},{"key":"bibr4-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07666-3"},{"key":"bibr5-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505253322102"},{"key":"bibr6-004947550403400203","first-page":"Sl","volume":"94","author":"Severe falciparum malaria","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"bibr7-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(97)00006-4"},{"key":"bibr8-004947550403400203","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.59.808"},{"key":"bibr9-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91719-O"},{"key":"bibr10-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg077"},{"key":"bibr11-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1997.11747910"},{"key":"bibr12-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90197-4"},{"key":"bibr13-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000090293.32810.4E"},{"key":"bibr14-004947550403400203","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.521"},{"key":"bibr15-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.4.334"},{"key":"bibr16-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.032516"},{"key":"bibr17-004947550403400203","author":"Musumba C","year":"2004","journal-title":"East African Med J"},{"key":"bibr18-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91638-B"},{"key":"bibr19-004947550403400203","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000102398.91277.08"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/004947550403400203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/004947550403400203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:27:34Z","timestamp":1777642054000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/004947550403400203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1177\/004947550403400203"],"URL":"https:\/\/doi.org\/10.1177\/004947550403400203","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}