{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:44:17Z","timestamp":1789825457095,"version":"4.0.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease that is now endemic in south eastern Iran. The most important factor associated with mortality is a platelet count of less than 50,000\/mL. The purpose of this study is to compare treated cases with severe thrombocytopenia using ribavirin with high-dose methylprednisolone (HDMP) with patients receiving ribavirin without HDMP. A clinical trial was conducted for confirmed patients with CCHF and severe thrombocytopenia (platelet count less than 50,000\/mL) admitted to Boo-Ali Hospital in Zahedan between January 2010 and October 2011. The intervention group was given oral ribavirin, supportive managements and HDMP and the controls were treated with ribavirin and supportive management. Following HDMP therapy in hospitalized patients with severe thrombocytopenia, the platelet count increased within 36\u2009h and the leukocyte count within 48\u2009h of the beginning of treatment. Fewer in the intervention group required a transfusion of blood products than in the controls ( P\u2009&lt;\u20090.001). No one in the intervention group died. It seems that high-dose methylprednisolone is effective in the treatment of patients with CCHF. The increased platelet count and reduction of blood product requirement for severe CCHF patients after receiving HDMP are promising results. Further investigation is necessary in order to determine the efficacy of corticosteroid and its effect on outcome.<\/jats:p>","DOI":"10.1177\/0049475513486642","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T21:16:29Z","timestamp":1370639789000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of high-dose methylprednisolone in patients with Crimean-Congo haemorrhagic fever and severe thrombocytopenia"],"prefix":"10.1177","volume":"43","author":[{"given":"Batool","family":"Sharifi-Mood","sequence":"first","affiliation":[{"name":"Professor of Infectious Diseases and Tropical Medicine, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Alavi-Naini","sequence":"additional","affiliation":[{"name":"Professor of Infectious Diseases and Tropical Medicine, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliheh","family":"Metanat","sequence":"additional","affiliation":[{"name":"Associate Professor of Infectious Diseases and Tropical Medicine, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Assistant Professor of Epidemiology and Biostatistics, Health Promotion Research Center, Zahedan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Shakeri","sequence":"additional","affiliation":[{"name":"Assistant Professor of Anesthesiology, Department of Anesthesiology, Zahedan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amjadi","sequence":"additional","affiliation":[{"name":"Resident of Infectious Diseases and Tropical Medicine, Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,6,7]]},"reference":[{"key":"bibr1-0049475513486642","first-page":"204","volume":"10","author":"Mardani M","year":"2007","journal-title":"Arch Iran Med"},{"key":"bibr2-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.07.015"},{"key":"bibr3-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181673c28"},{"key":"bibr4-0049475513486642","first-page":"151","volume":"12","author":"Sharifi-Mood B","year":"2009","journal-title":"Arch Iranian Med"},{"key":"bibr5-0049475513486642","first-page":"193","volume":"2","author":"Sharifi Mood B","year":"2007","journal-title":"Iranian J Clin Infect Dis"},{"key":"bibr6-0049475513486642","first-page":"201","volume":"20","author":"Sheikh AS","year":"2004","journal-title":"Pak J Med Sci"},{"key":"bibr7-0049475513486642","first-page":"1898","volume":"9","author":"Sharifi-Mood B","year":"2006","journal-title":"A seven-year experience. Pakistan J Bio Sci"},{"key":"bibr8-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1086\/422000"},{"key":"bibr9-0049475513486642","first-page":"27","volume":"32","author":"Centers for Disease Control and Prevention","year":"1983","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr10-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1086\/375058"},{"key":"bibr11-0049475513486642","first-page":"258","volume-title":"Crimean-Congo Hemorrhagic Fever: A Global Perspective","author":"Mirazimi A","year":"2007"},{"key":"bibr12-0049475513486642","doi-asserted-by":"crossref","first-page":"439","DOI":"10.7883\/yoken.64.439","volume":"64","author":"Kubar A","year":"2011","journal-title":"Jpn J Infect Dis"},{"key":"bibr13-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.05.003"},{"key":"bibr14-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-6106-6_16"},{"key":"bibr15-0049475513486642","doi-asserted-by":"crossref","unstructured":"Pantanowitz L. Mechanisms of thrombocytopenia in tick-borne diseases. Internet J Infect Dis 2003; 2. http:\/\/www.ispub.com\/ostia\/index.php (last accessed on 18 October 2004).","DOI":"10.5580\/b"},{"key":"bibr16-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1258\/td.2009.090069"},{"key":"bibr17-0049475513486642","doi-asserted-by":"publisher","DOI":"10.3923\/ijv.2006.21.24"},{"key":"bibr18-0049475513486642","doi-asserted-by":"crossref","first-page":"11","DOI":"10.7883\/yoken.JJID.2009.11","volume":"62","author":"Izadi S","year":"2009","journal-title":"Jpn J Infect Dis"},{"key":"bibr19-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2008.11.001"},{"key":"bibr20-0049475513486642","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00530-09"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475513486642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475513486642","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475513486642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:28:30Z","timestamp":1777642110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475513486642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1177\/0049475513486642"],"URL":"https:\/\/doi.org\/10.1177\/0049475513486642","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}