{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:04:14Z","timestamp":1777907054453,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension followed by shock and the other had facial angioedema with chest tightness during treatment. Both patients were managed with immediate action of injection: adrenaline, diphenhydramine and hydrocortisone. In our experience, AmBisome can cause severe hypersensitivity reactions that warrant proper support and close supervision.<\/jats:p>","DOI":"10.1177\/0049475514543655","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:30:13Z","timestamp":1408494613000},"page":"241-242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion"],"prefix":"10.1177","volume":"44","author":[{"given":"Proggananda","family":"Nath","sequence":"first","affiliation":[{"name":"Medical Officer, Surya Kanta Kala-azar Research Centre, Mymensingh Medical College Hospital, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariful","family":"Basher","sequence":"additional","affiliation":[{"name":"Registrar & Incharge, Department of Infectious and Tropical Diseases, Mymensingh Medical College Hospital, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Harada","sequence":"additional","affiliation":[{"name":"Research Fellow, Department of Hemodialysis & Apheresis, The University of Tokyo Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santana","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Medical Officer, Surya Kanta Kala-azar Research Centre, Mymensingh Medical College Hospital, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahjada","family":"Selim","sequence":"additional","affiliation":[{"name":"Registrar, Department of Medicine, Shaheed Suhrawardy Medical College Hospital, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Maude","sequence":"additional","affiliation":[{"name":"Senior Clinical Research Fellow, Mahidol-Oxford Tropical Medicine Research Unit, Thailand"},{"name":"Senior Clinical Research Fellow and Honorary Consultant Physician, Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisei","family":"Noiri","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Hemodialysis & Apheresis, The University of Tokyo Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abul","family":"Faiz","sequence":"additional","affiliation":[{"name":"Professor and Director General of Health Services (Retired), Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"bibr1-0049475514543655","volume-title":"National Guideline for Kala-azar Case Management, Kala-azar Elimination Program","author":"Bangladesh Ministry of Health and Family Welfare","year":"2013"},{"key":"bibr2-0049475514543655","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.16.2821"},{"key":"bibr3-0049475514543655","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.06.003"},{"key":"bibr4-0049475514543655","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70064-1"},{"key":"bibr5-0049475514543655","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-8-664"},{"key":"bibr6-0049475514543655","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(64)80115-7"},{"key":"bibr7-0049475514543655","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1398-9995.2010.02418.x","volume":"65","author":"Waserman S","year":"2010","journal-title":"Allergy"},{"key":"bibr8-0049475514543655","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84138-5_41"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475514543655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475514543655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475514543655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:29:04Z","timestamp":1777642144000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475514543655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,19]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1177\/0049475514543655"],"URL":"https:\/\/doi.org\/10.1177\/0049475514543655","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,19]]}}}