{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:08:57Z","timestamp":1792588137717,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the clinical and biochemical characteristics of Yemeni adults and children with visceral leishmaniasis (VL) and the differences between them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cross-sectional study on patients with bone marrow aspirate confirmed VL evaluated at Al-Jomhori Teaching Hospital in Sana\u2019a, Yemen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-eight (59.6%) patients were adults with a mean age (\u00b1 SD) of 24.3 years\u2009\u00b1\u20099.2 and 19 (40.4%) patients were children with a mean age (\u00b1 SD) of 7.1 years \u00b1 4.7. Fever, pallor, splenomegaly and hepatomegaly were the most common clinical findings. Hypoalbuminaemia, hyperglobulinaemia, elevated LDH, hypocalcaemia and elevated CRP were common biochemical abnormalities. There was no significant difference in splenomegaly size or biochemical parameters with regard to grade of parasitic load. Both children and adults showed similar significant improvement after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biochemical abnormalities were not related to degree of parasitic load and there were no clinical, biochemical or treatment differences between adults and children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0049475515622862","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T20:08:03Z","timestamp":1452283683000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The clinical and biochemical characteristics of Yemeni adults and children with visceral leishmaniasis and the differences between them: a prospective cross-sectional study before and after treatment"],"prefix":"10.1177","volume":"46","author":[{"given":"Jameel","family":"Al-Ghazaly","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"},{"name":"Department of Medicine, Al-Jomhori Teaching Hospital, Sana\u2019a, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waled","family":"Al-Dubai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cytogenetics, Faculty of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-0049475515622862","doi-asserted-by":"crossref","DOI":"10.1596\/9778","volume-title":"The World Health Report","author":"World Health Organization","year":"2002"},{"key":"bibr2-0049475515622862","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1748"},{"key":"bibr3-0049475515622862","first-page":"1","volume":"949","author":"World Health Organization","year":"2010","journal-title":"World Health Organ Tech Rep Ser"},{"key":"bibr4-0049475515622862","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"bibr5-0049475515622862","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S44267"},{"key":"bibr6-0049475515622862","first-page":"761","volume":"58","author":"Polak P","year":"2012","journal-title":"Vnitr Lek"},{"key":"bibr7-0049475515622862","first-page":"353","volume":"123","author":"Bhattacharya SK","year":"2006","journal-title":"Indian J Med Res"},{"key":"bibr8-0049475515622862","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/38.1.17"},{"key":"bibr9-0049475515622862","first-page":"105","volume":"11","author":"Rageh HA","year":"1990","journal-title":"Saudi Med J"},{"key":"bibr10-0049475515622862","first-page":"516","volume":"22","author":"Haidar NA","year":"2001","journal-title":"Saudi Med J"},{"key":"bibr11-0049475515622862","first-page":"25","volume":"26","author":"Abdul Hamid G","year":"2009","journal-title":"Turk J Hematol"},{"key":"bibr12-0049475515622862","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00823.x"},{"key":"bibr13-0049475515622862","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2012.751033"},{"key":"bibr14-0049475515622862","volume-title":"Statistical Year Book 2012","author":"Central Statistical Organization","year":"2010"},{"key":"bibr15-0049475515622862","unstructured":"Bishop ML, Duben-Enelkrik JL and Fody EP (eds).\n                      Clinical Chemistry: Principles, Procedures, Correlations\n                      . 4th ed. 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