{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:47:17Z","timestamp":1787888837117,"version":"build-2784847793"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>A comparison of induction of labour (IOL) using three doses of 25\u2009\u00b5g vaginal misoprostol inserted at intervals of 4\u2009h or more with a stepwise oral regime starting with 50\u2009\u00b5g followed by two doses of 100\u2009\u00b5g was studied in a double-blind placebo-controlled trial in a tertiary centre in South India. Primary outcome was vaginal delivery in 24\u2009h. Significantly more women in the first group required oxytocin augmentation and a third dose of the drug than women in the second group. Uterine tachysystole and other maternal and neonatal complications were similar. Thus it is concluded that women induced with oral, as compared to vaginal misoprostol are more likely to labour without oxytocin.<\/jats:p>","DOI":"10.1177\/0049475515624856","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T21:20:00Z","timestamp":1453238400000},"page":"198-205","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A randomised double-blind placebo-controlled trial comparing stepwise oral misoprostol with vaginal misoprostol for induction of labour"],"prefix":"10.1177","volume":"46","author":[{"given":"Hilda","family":"Yenuberi","sequence":"first","affiliation":[{"name":"Registrar, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Abraham","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh J","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visalakshi","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Lecturer, Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiji E","family":"Mathews","sequence":"additional","affiliation":[{"name":"Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-0049475515624856","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30265-3"},{"key":"bibr2-0049475515624856","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440107"},{"key":"bibr3-0049475515624856","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00374-2"},{"key":"bibr4-0049475515624856","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01111.x"},{"issue":"10","key":"bibr5-0049475515624856","first-page":"CD000941. doi:","author":"Hofmeyr GJ","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-0049475515624856","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.011"},{"key":"bibr7-0049475515624856","unstructured":"World Health Organization.\n                      WHO recommendations for induction of labour\n                      . 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