{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:05:07Z","timestamp":1777907107145,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>We sought to determine the incidence and clinical spectrum of the paradoxical reaction (PR) to treatment in 1000 children with tuberculosis (TB). Its incidence was 3.3%, presenting as mediastinal adenopathy (n\u2009=\u200912), central nervous system (CNS) tuberculoma (n\u2009=\u20098), increasing size of lymph nodes (n\u2009=\u20098) and serositis (n\u2009=\u20095). Symptoms included breathlessness (n\u2009=\u20097, 21.2%), neck swellings (n\u2009=\u20095, 15.2%), hemiplegia (n\u2009=\u20093, 9.1%), raised intracranial tension (n\u2009=\u20092, 6.1%) and fever or diabetes insipidus (n\u2009=\u20091, 3% each). The mean age of onset of PR was 3.5 months after the start of anti-TB medication. PR was seen predominantly in boys. Mediastinal lymphadenopathy was more common in children aged &lt;2 years. Tuberculomas were more common in children aged 2\u20135 years. Nodal enlargement and serositis were seen equally in all age groups.<\/jats:p>","DOI":"10.1177\/0049475516676388","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T20:38:30Z","timestamp":1478983110000},"page":"109-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Paradoxical reactions in children with tuberculosis"],"prefix":"10.1177","volume":"47","author":[{"given":"Ira","family":"Shah","sequence":"first","affiliation":[{"name":"Paediatric TB Clinic, BJ Wadia Hospital for Children, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MV","family":"Bhaskar","sequence":"additional","affiliation":[{"name":"Paediatric TB Clinic, BJ Wadia Hospital for Children, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,12]]},"reference":[{"key":"bibr1-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0821-2"},{"key":"bibr2-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0998-z"},{"key":"bibr3-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/16.1.179"},{"key":"bibr4-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.6.1092"},{"key":"bibr5-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3.933"},{"key":"bibr6-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.4.774"},{"key":"bibr7-0049475516676388","first-page":"599","volume":"59","author":"Onwubalili JK","year":"1986","journal-title":"Q J Med"},{"key":"bibr8-0049475516676388","first-page":"1437","author":"Barss P","year":"1983","journal-title":"Lancet"},{"key":"bibr9-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1086\/429317"},{"key":"bibr10-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.223.199"},{"key":"bibr11-0049475516676388","first-page":"257","volume":"51","author":"Gupta M","year":"2003","journal-title":"J Assoc Physicians India"},{"key":"bibr12-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.019224"},{"key":"bibr13-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.1.9712001"},{"key":"bibr14-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-010-0330-8"},{"key":"bibr15-0049475516676388","first-page":"240","volume":"76","author":"Moreno C","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"bibr16-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.9.3348"},{"key":"bibr17-0049475516676388","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2008.64.6.427"},{"key":"bibr18-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.05.006"},{"key":"bibr19-0049475516676388","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0033-8389(22)00616-9","volume":"33","author":"Dastur DK","year":"1995","journal-title":"Radiol Clin North Am"},{"key":"bibr20-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(77)90041-1"},{"key":"bibr21-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(96)90289-9"},{"key":"bibr22-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1086\/515543"},{"key":"bibr23-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2013.07.021"},{"key":"bibr24-0049475516676388","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.01.018"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475516676388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475516676388","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475516676388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:30:14Z","timestamp":1777642214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475516676388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,12]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1177\/0049475516676388"],"URL":"https:\/\/doi.org\/10.1177\/0049475516676388","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,12]]}}}