{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:52:03Z","timestamp":1781812323227,"version":"3.54.5"},"reference-count":5,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of unchecked activation of the immune system leading to phagocytosis of blood cells and proliferation of histiocytes in solid organs. HLH can be primary or secondary to infective, autoimmune and malignant conditions. Scrub typhus is an infective illness caused by Orientia tsutsugamushi, transmitted by mite. The illness ranges from mild fever with rash to severe multisystem illness. Scrub typhus has rarely been associated with secondary HLH. We report an infant with scrub typhus who progressed to develop HLH with central nervous system involvement with fatal outcome.<\/jats:p>","DOI":"10.1177\/0049475518804696","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T03:16:56Z","timestamp":1540523816000},"page":"52-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: a rare fatal occurrence"],"prefix":"10.1177","volume":"49","author":[{"given":"Shipra","family":"Agrwal","sequence":"first","affiliation":[{"name":"Senior Resident, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashima","family":"Dabas","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Mantan","sequence":"additional","affiliation":[{"name":"Professor, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Director Professor and Head, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"bibr1-0049475518804696","doi-asserted-by":"publisher","DOI":"10.4103\/jnrp.jnrp_44_17"},{"key":"bibr2-0049475518804696","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-011-0141-7"},{"key":"bibr3-0049475518804696","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fms030"},{"key":"bibr4-0049475518804696","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.02.009"},{"key":"bibr5-0049475518804696","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trx066"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475518804696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475518804696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475518804696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:31:16Z","timestamp":1777642276000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475518804696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/0049475518804696"],"URL":"https:\/\/doi.org\/10.1177\/0049475518804696","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]}}}