{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:06:32Z","timestamp":1777907192091,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Chronic hepatitis C (HCV) patients commonly have insulin resistance which is a risk factor for disease progression. Oesophageal varices may bleed with high mortality. We aimed to assess the relationship between insulin resistance and oesophageal varices. HCV-related compensated liver cirrhosis patients (n\u2009=\u2009146) underwent gastroscopy and homeostasis model assessment (HOMA)-IR, HOMA-\u03b2 and HOMA-S calculations. Their average age was 54.98 years; most (84.9%) patients were men and non-diabetic (60.3%). Patients with oesophageal varices had higher median Model for End-Stage Liver Disease (MELD) scores and comparable Child-Pugh class. Patients with and without oesophageal varices had comparable ( P\u2009&gt;\u20090.05) HOMA scores and insulin resistance percentage of 82.9% versus 85.5%. We therefore conclude that insulin resistance is unrelated to the presence of oesophageal varices.<\/jats:p>","DOI":"10.1177\/0049475519863231","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T01:26:05Z","timestamp":1562894765000},"page":"281-285","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Insulin resistance is not a risk factor for oesophageal varices development in hepatitis C"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-2312","authenticated-orcid":false,"given":"Ayman","family":"Alsebaey","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen El-Koom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Elhelbawy","sequence":"additional","affiliation":[{"name":"Lecturer, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen El-Koom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"bibr1-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"bibr2-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.004"},{"key":"bibr3-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001215"},{"key":"bibr4-0049475519863231","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i1.52"},{"key":"bibr5-0049475519863231","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i16.1943"},{"key":"bibr6-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"bibr7-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"bibr8-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gow018"},{"key":"bibr9-0049475519863231","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.362"},{"key":"bibr10-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109263251307"},{"key":"bibr11-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14067"},{"key":"bibr12-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22655"},{"key":"bibr13-0049475519863231","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.17738"},{"key":"bibr14-0049475519863231","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000627"},{"key":"bibr15-0049475519863231","doi-asserted-by":"publisher","DOI":"10.2174\/1871530318666180803120428"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475519863231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475519863231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475519863231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:31:46Z","timestamp":1777642306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475519863231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,11]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1177\/0049475519863231"],"URL":"https:\/\/doi.org\/10.1177\/0049475519863231","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,11]]}}}