{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:07:55Z","timestamp":1777907275606,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>A 12-week course of miltefosine (MF) is recommended in India for the treatment of post-kala-azar dermal leishmaniasis (PKDL). We report a case series of four patients with PKDL, across three districts of Bihar state, who developed eye complications during treatment. They presented with acute scleritis and corneal infiltration with or without corneal ulceration. One patient solely with corneal infiltration recovered completely. The three others with corneal ulceration healed with corneal opacificity. One patient with bilateral eye involvement underwent corneal transplantation to prevent blindness. All adverse events were graded as certain using the World Health Organization-Uppsala Monitoring Centre causality assessment scale. There is need to counsel patients regarding possible adverse ocular events during MF treatment, to expand pharmacovigilance to all primary health centres in kala-azar endemic areas, and to update drug safety information considering the emerging evidence.<\/jats:p>","DOI":"10.1177\/0049475519877317","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T01:24:12Z","timestamp":1571102652000},"page":"37-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Adverse ocular events on miltefosine treatment for post-kala-azar dermal leishmaniasis in India"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-6783","authenticated-orcid":false,"given":"Suman","family":"Saurabh","sequence":"first","affiliation":[{"name":"Zonal Coordinator, Neglected Tropical Diseases, World Health Organization, Muzaffarpur, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Mahabir","sequence":"additional","affiliation":[{"name":"Medical Director, Mahavir Netralaya, Darbhanga, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"bibr1-0049475519877317","unstructured":"World Health Organization. Post-kala-azar dermal leishmaniasis: a manual for case management and control: report of a WHO consultative meeting, Kolkata, India, 2\u20133 July 2012. Geneva: WHO, 2013. Available at: http:\/\/www.who.int\/neglected_diseases\/resources\/9789241505215 \/en\/ (accessed August 2019)."},{"key":"bibr2-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00517-6"},{"key":"bibr3-0049475519877317","unstructured":"World Health Organization. Process of validation of elimination of kala-azar as a public health problem in South-East Asia. New Delhi: WHO South East Asia Regional Office (SEARO), 2016. Available at: http:\/\/www.who.int\/leishmaniasis\/resources\/Process_of_validation_of_VL_elimination_SEA_CD_321.pdf?ua=1&ua=1 (accessed August 2019)."},{"key":"bibr4-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1159\/000420840"},{"key":"bibr5-0049475519877317","unstructured":"Directorate of National Vector Borne Disease Control Programme.\n                      National Roadmap for Kala-azar Elimination August 2014\n                      . New Delhi: Ministry of Health and Family Welfare, Government of India, 2014. Available at: http:\/\/www.nvbdcp.gov.in\/Doc\/Road-map-KA_2014.pdf (accessed August 2019)."},{"key":"bibr6-0049475519877317","unstructured":"Directorate of National Vector Borne Disease Control Programme.\n                      Accelerated Plan for Kala-azar Elimination 2017\n                      . New Delhi: Government of India, 2017. Available at: http:\/\/www.nvbdcp.gov.in\/Doc\/Accelerated-Plan-Kala-azar1-Feb2017.pdf (accessed August 2019)."},{"key":"bibr7-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks275"},{"key":"bibr8-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.02.010"},{"key":"bibr9-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001396"},{"key":"bibr10-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006781"},{"key":"bibr11-0049475519877317","unstructured":"World Health Organization. The use of the WHO-UMC system for standardized case causality assessment. World Health Organization (WHO)\u2009-\u2009Uppsala Monitoring Centre. Available at: https:\/\/www.who.int\/medicines\/areas\/quality_safety\/safety_efficacy\/WHOcausality_assessment.pdf (accessed August 2019)."},{"key":"bibr12-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr13-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.11.008"},{"key":"bibr14-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.08.013"},{"key":"bibr15-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1177\/019262339702500111"},{"key":"bibr16-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142317"},{"key":"bibr17-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-44106-0_2"},{"key":"bibr18-0049475519877317","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007173"},{"key":"bibr19-0049475519877317","unstructured":"Directorate of National Vector Borne Diseases Control Programme of India.\n                      Kala-azar situation in India\n                      . New Delhi: Ministry of Health and Family Welfare, Government of India, 2019. Available at: https:\/\/www.nvbdcp.gov.in\/index4.php?lang=1&level=0&linkid=467 &lid=3750 (accessed August 2019)."}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475519877317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475519877317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475519877317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:31:53Z","timestamp":1777642313000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475519877317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,14]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/0049475519877317"],"URL":"https:\/\/doi.org\/10.1177\/0049475519877317","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,14]]}}}