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The most common risk for the development of progressive disseminated form is HIV infection. We recently managed two patients with disseminated histoplasmosis, presenting with prolonged fever, significant weight loss, pallor and hepatosplenomegaly. Both were HIV-negative and lived in Himachal Pradesh (India), a region that was considered \u201c Histoplasma-free\u201d until recently.<\/jats:p>","DOI":"10.1177\/0049475520908725","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:51:06Z","timestamp":1582678266000},"page":"275-277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Pyrexia of unknown origin in HIV-negative adults from Himachal Pradesh (India): will you suspect disseminated histoplasmosis?"],"prefix":"10.1177","volume":"50","author":[{"given":"Navneet","family":"Arora","sequence":"first","affiliation":[{"name":"Senior Resident, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubham","family":"Shukla","sequence":"additional","affiliation":[{"name":"Resident, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeksha","family":"Vijaykumar","sequence":"additional","affiliation":[{"name":"Resident, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Suri","sequence":"additional","affiliation":[{"name":"Additional Professor, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-3478","authenticated-orcid":false,"given":"Ashok K","family":"Pannu","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"bibr1-0049475520908725","first-page":"91","volume":"90","author":"Hersch EC","year":"2014","journal-title":"Am Fam Physician"},{"key":"bibr2-0049475520908725","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2007.08.001"},{"key":"bibr3-0049475520908725","doi-asserted-by":"publisher","DOI":"10.1086\/500405"},{"key":"bibr4-0049475520908725","first-page":"71","volume":"7","author":"Randhawa HS","year":"2018","journal-title":"J Med Res Prac"},{"key":"bibr5-0049475520908725","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0432"},{"key":"bibr6-0049475520908725","first-page":"69","volume":"63","author":"John M","year":"2015","journal-title":"J Assoc Physicians India"},{"key":"bibr7-0049475520908725","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.009"},{"key":"bibr8-0049475520908725","first-page":"159","volume":"2","author":"Jombo GTA","year":"2010","journal-title":"J Clin Med Res"},{"key":"bibr9-0049475520908725","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"bibr10-0049475520908725","doi-asserted-by":"crossref","unstructured":"McKinsey DS and Pappas PG. 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