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We compared data from 733 children in 2010 and 972 children in 2018 to determine the effect of repeated praziquantel treatment on prevalence of liver disease. Three age groups were compared across three liver disease classifications (normal, mild, severe). From 2010 to 2018, there was a significant reduction in prevalence of severe liver disease in all age groups ( P\u2009=\u20090.03 for 5\u201310 years, P\u2009&lt;\u20090.001 for 11\u201315 years and 16\u201320 years). In both male and female students, the proportion having a normal liver significantly increased ( P\u2009&lt;\u20090.001) from 2010 to 2018, in the 11\u201315-year-olds and 16\u201320-year-olds, demonstrating that liver disease significantly reduced in these age groups. This study demonstrates a reduction in schistosomiasis-related morbidity with repeated praziquantel treatment.<\/jats:p>","DOI":"10.1177\/0049475520921281","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T09:18:07Z","timestamp":1588324687000},"page":"216-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Change in schistosomiasis-related liver disease with repeated praziquantel treatment in school children in rural Zambia"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-9700","authenticated-orcid":false,"given":"Rodney","family":"Strahan","sequence":"first","affiliation":[{"name":"Radiology, Chitokoloki Mission Hospital, Chitokoloki, North Western Province, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McAdam","sequence":"additional","affiliation":[{"name":"Medical Director, Chitokoloki Mission Hospital, Chitokoloki, North Western Province, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldho","family":"Paul","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"bibr1-0049475520921281","unstructured":"World Health Organization.\n                      Schistosomiasis Fact Sheet\n                      . 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