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We present five such cases which were refractory to conventional intravenous antibiotic therapy, had persistent features of ventriculitis and in whom raised intracranial pressure (ICP) necessitated insertion of an external ventricular drain (EVD). Three of the five infants required intraventricular antibiotics but also developed EVD-related complications. Early diagnosis of ventriculitis and treatment is necessary to avoid a fatal outcome. Intravenous antibiotics are the treatment of choice, but intraventricular therapy may be considered in refractory cases. As the incidence of EVD-associated ventriculitis is high, proper care of EVDs and their early removal is mandatory.<\/jats:p>","DOI":"10.1177\/0049475520927626","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T01:41:40Z","timestamp":1590975700000},"page":"266-270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Neonatal ventriculitis: a case series and review of literature"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-7953","authenticated-orcid":false,"given":"Ramitha R","family":"Bhat","sequence":"first","affiliation":[{"name":"Senior Resident, Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, 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