{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:40:30Z","timestamp":1793029230688,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The aetiology of pyrexia of unknown origin (PUO) varies dramatically according to epidemiology. We studied the cause and spectrum of PUO in Indian adults. A total of 152 patients (112 prospectively and 40 retrospectively) met Petersdorf and Beeson's criteria. The diagnostic evaluation was guided by potentially diagnostic clues, based on a \u2018step-wise\u2019 approach. The five main categories, i.e. infectious, neoplastic, non-infectious inflammatory, miscellaneous and undiagnosed comprised 43.4%, 21.5%, 19.7%, 2.0% and 12.5%, respectively. The top three causes were tuberculosis (n\u2009=\u200943, 28.3%), lymphoma (n\u2009=\u200919, 12.5%) and adult-onset Still's disease (n\u2009=\u200912, 7.9%). Tuberculosis predominated in all age groups, and about 70% of cases had the extrapulmonary form, the most common being gastrointestinal. Hodgkin and non-Hodgkin lymphomas were equally distributed, but solid malignancies were uncommon. Adult-onset Still's disease was the second commonest cause in adults aged\u2009\u2264\u200940 years. Fever resolved spontaneously in 12\/19 cases of undiagnosed cause. Extrapulmonary tuberculosis remains the most prevalent PUO in India.<\/jats:p>","DOI":"10.1177\/0049475520947907","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T01:34:52Z","timestamp":1597714492000},"page":"34-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Aetiology of pyrexia of unknown origin in north India"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-3478","authenticated-orcid":false,"given":"Ashok Kumar","family":"Pannu","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithvik","family":"Golla","sequence":"additional","affiliation":[{"name":"Resident, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Kumari","sequence":"additional","affiliation":[{"name":"Professor, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Suri","sequence":"additional","affiliation":[{"name":"Additional Professor, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"bibr1-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196102000-00001"},{"key":"bibr2-0049475520947907","first-page":"35","volume":"11","author":"Durack DT","year":"1991","journal-title":"Curr Clin Top Infect Dis"},{"key":"bibr3-0049475520947907","first-page":"91","volume":"90","author":"Hersch EC","year":"2014","journal-title":"Am Fam Physician"},{"key":"bibr4-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31802fe858"},{"key":"bibr5-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.06.001"},{"key":"bibr6-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198209000-00001"},{"key":"bibr7-0049475520947907","first-page":"185","volume":"15","author":"Barbado FJ","year":"1984","journal-title":"J Med"},{"key":"bibr8-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400130077008"},{"key":"bibr9-0049475520947907","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.33.67"},{"key":"bibr10-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199711000-00002"},{"key":"bibr11-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.9.1033"},{"key":"bibr12-0049475520947907","doi-asserted-by":"publisher","DOI":"10.1177\/004947559602600411"},{"key":"bibr13-0049475520947907","first-page":"104","volume":"47","author":"Kejariwal D","year":"2001","journal-title":"J Postgrad Med"},{"key":"bibr14-0049475520947907","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.91052"},{"key":"bibr15-0049475520947907","unstructured":"Central TB Division, Ministry of health & family Welfare, Government of India.\n                      Guidelines: Technical and Operational Guidelines for TB Control in India 2016\n                      . 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