{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:08:54Z","timestamp":1777907334881,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>In 2016, the World Health Organization adopted dolutegravir (DTG)-based antiretroviral therapy as an alternative first-line treatment of HIV after many clinical trials showed that it was more effective, better tolerated and more protective than efavirenz and boosted protease inhibitors against discontinuation of treatment from adverse drug reactions. However, there was concern that DTG would lead to increased rates of immune reconstitution inflammatory syndrome (IRIS), especially in the setting of late presentation to care. Three cases at the University Teaching Hospital in Lusaka, Zambia highlight this concern, especially in persons living with HIV (PLWH), resulting in tuberculosis (TB) co-infection.<\/jats:p>","DOI":"10.1177\/0049475520953704","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T15:00:26Z","timestamp":1599663626000},"page":"216-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune reconstitution inflammatory syndrome: a report of TB-IRIS after switching from efavirenz to dolutegravir"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6861-6416","authenticated-orcid":false,"given":"Stanley","family":"Zimba","sequence":"first","affiliation":[{"name":"Internal Medicine Consultant and Neurology Registrar, Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nyuma","family":"Mbewe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Registrar, Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Chishimba","sequence":"additional","affiliation":[{"name":"Neurology Registrar, Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mashina","family":"Chomba","sequence":"additional","affiliation":[{"name":"Neurology Registrar, Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna","family":"Saylor","sequence":"additional","affiliation":[{"name":"Honorary Consultant, University Teaching Hospital, Lusaka, Zambia"},{"name":"Assistant Professor of Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"bibr1-0049475520953704","unstructured":"Walmsley S, Berenguer J, Kilby JM, et al. Dolutegravir Regimen Statistically Superior to Efavirenz\/Tenofovir\/Emtricitabine: 96-Week Results From the SINGLE Study (ING114467).\n                      21st Conference on Retroviruses and Opportunistic Infection, Boston, Massachusetts\n                      . 2014; 75: 114467."},{"key":"bibr2-0049475520953704","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000519"},{"key":"bibr3-0049475520953704","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-016-0115-x"},{"key":"bibr4-0049475520953704","unstructured":"Wijting IEA, Wit FWNM, Rokx C,\n                      et\u00a0al\n                      . Use of integrase inhibitors is an independent risk factor for immune reconstitution inflammatory syndrome (IRIS) in HIV-1 late presenters: an ATHENA cohort study. In\n                      16th European AIDS Conference\n                      , Milan, Italy 2017; 25: 313s."},{"key":"bibr5-0049475520953704","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170329142059"},{"key":"bibr6-0049475520953704","first-page":"405","volume":"15","author":"Psichogiou M","year":"2017","journal-title":"Curr HIV Res"},{"key":"bibr7-0049475520953704","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61221-0"},{"key":"bibr8-0049475520953704","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.11.003"},{"key":"bibr9-0049475520953704","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000445"},{"key":"bibr10-0049475520953704","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.9"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475520953704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0049475520953704","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475520953704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:32:37Z","timestamp":1777642357000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0049475520953704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1177\/0049475520953704"],"URL":"https:\/\/doi.org\/10.1177\/0049475520953704","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]}}}