{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:18:53Z","timestamp":1784704733155,"version":"3.55.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Whilst nausea affects around 80% of pregnant women, hyperemesis gravidarum, an extreme form of the same, affects only 0.5% to 3%, but may lead to severe nutritional deficiency. Wernicke\u2019s encephalopathy is an acute neuropsychiatric disorder which occurs due to thiamine deficiency and needs emergency treatment to prevent neurological morbidity and mortality. Wernicke\u2019s encephalopathy is characterised by a clinical triad of oculomotor abnormalities, cerebellar dysfunction and altered mental state. Korsakoff\u2019s psychosis is a chronic condition and consequence of Wernicke\u2019s encephalopathy, resulting from its delayed treatment. Wernicke\u2019s encephalopathy is a well-known complication of chronic alcohol abuse. Not many are aware of its association with hyperemesis gravidarum. Although it is a rare complication, if not diagnosed and treated promptly, it may result in permanent and irreversible neurological sequelae. The objective of our retrospective observational study was to analyse the clinical profile and outcome (short and long term) in a rare yet preventable complication of pregnancy.<\/jats:p>","DOI":"10.1177\/00494755211014396","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T02:33:57Z","timestamp":1624588437000},"page":"98-100","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Wernicke\u2019s encephalopathy in women with hyperemesis gravidarum \u2013 Case series and literature review"],"prefix":"10.1177","volume":"52","author":[{"given":"Makarand Anil","family":"Rane","sequence":"first","affiliation":[{"name":"Senior Resident, Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Kishan","family":"Boorugu","sequence":"additional","affiliation":[{"name":"Consultant Physician, Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Ravishankar","sequence":"additional","affiliation":[{"name":"Consultant Physician, Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tarakeswari","sequence":"additional","affiliation":[{"name":"Consultant Obstetrician, Head, Department of Obstetric Medicine, Fernandez hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemamalini","family":"Vadlamani","sequence":"additional","affiliation":[{"name":"Consultant Physician, Fernandez Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemalatha","family":"Anand","sequence":"additional","affiliation":[{"name":"Consultant Physician, Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"bibr1-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.1.51"},{"key":"bibr2-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi021"},{"key":"bibr3-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70104-7"},{"key":"bibr4-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.04.008"},{"key":"bibr5-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.03.006"},{"key":"bibr6-00494755211014396","unstructured":"Sulaiman W, Othman A, Mohamad M, et al. Wernicke's encephalopathy associated with hyperemesis gravidarum - a case report.\n                      Malays J Med Sci\n                      2002; 9: 43-46."},{"key":"bibr7-00494755211014396","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.191005"},{"key":"bibr8-00494755211014396","unstructured":"Victor M, Adams RA and Collins GH.\n                      The Wernicke Korsakoff syndrome and related disorders due to alcoholism and malnutrition.\n                      Philadelphia, PA: FA Davis, 1989."},{"key":"bibr9-00494755211014396","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.171.4.9763009"},{"key":"bibr10-00494755211014396","unstructured":"Gallucci M, Bozzao A, Splendiani A, et al. Wernicke encephalopathy: MR findings in five patients.\n                      Am J Neuroradiol\n                      1999; 11: 887."},{"key":"bibr11-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04095.x"},{"key":"bibr12-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2001.tb00070.x"},{"key":"bibr13-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.6.513"},{"key":"bibr14-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a008400"},{"key":"bibr15-00494755211014396","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099189.56741.A7"},{"key":"bibr16-00494755211014396","unstructured":"Royal College of Obstetricians and Gynaecologists. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum (Green-top Guideline 69) London: RCOG; 2016. https:\/\/www.rcog.org.uk\/en\/guidelines-research-services\/guidelines\/gtg69\/."}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755211014396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755211014396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755211014396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:33:19Z","timestamp":1777642399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755211014396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,24]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/00494755211014396"],"URL":"https:\/\/doi.org\/10.1177\/00494755211014396","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,24]]}}}