{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:09:35Z","timestamp":1777907375645,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>High-grade malignancy is endemic in sub-Saharan Africa and is prone to the spontaneous tumour lysis syndrome. However, data on spontaneous tumour lysis syndrome remain scanty in our setting. We sought to determine the prevalence and factors associated with laboratory spontaneous tumour lysis syndrome in children in Uganda. We conducted a cross-sectional study among children &lt;18 years old with histologically confirmed high-grade malignancy between October 2013 and April 2014. Laboratory spontaneous tumour lysis syndrome was defined as the presence of \u22652 of each of hyperkalaemia, hypocalcaemia, hyperuricaemia and hyperphosphatemia prior to administration of chemotherapy when alternative diagnoses had been excluded. A p\u2009&lt;\u20090.05 was considered statistically significant. Of 108 children, of median age 7.7 years, where boys outnumbered girls 2:1, high-grade, malignancy included Burkitt\u2019s lymphoma, acute lymphoblastic leukaemia, non-Hodgkin\u2019s lymphoma, acute myeloid leukaemia and Burkitt\u2019s leukaemia, with 14 suffering with laboratory spontaneous tumour lysis syndrome. Hypocalcaemia was its most common electrolyte imbalance; and four children died prior to commencement of chemotherapy. Bulky disease, lactate dehydrogenase levels \u2265500\u2009iu\/l and serum creatinine levels &gt;1.2\u2009mg\/dl were associated with laboratory spontaneous tumour lysis syndrome. However, only bulky disease was significantly predictive of laboratory spontaneous tumour lysis syndrome. Such children would benefit from routine screening.<\/jats:p>","DOI":"10.1177\/00494755211029782","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T02:54:07Z","timestamp":1625712847000},"page":"501-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of laboratory spontaneous tumour lysis syndrome in children with high-grade tumours in Uganda"],"prefix":"10.1177","volume":"51","author":[{"given":"Mirriam","family":"Apiyo","sequence":"first","affiliation":[{"name":"Paediatrician, Department of Paediatrics and Child Health, Case Hospital, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4515-8517","authenticated-orcid":false,"given":"Felix","family":"Bongomin","sequence":"additional","affiliation":[{"name":"Lecturer, Department of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda"},{"name":"Lecturer, Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Balagadde","sequence":"additional","affiliation":[{"name":"Paediatrician, Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezekiel","family":"Mupere","sequence":"additional","affiliation":[{"name":"Senior Lecturer\/Paediatrician, Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Ndeezi","sequence":"additional","affiliation":[{"name":"Professor\/Paediatrician, Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"bibr1-00494755211029782","unstructured":"International Agency for Research on Cancer. GLOBOCAN 2020: estimated cancer incidence, mortality and prevalence worldwide in 2018.\n                      Int Agency Res Cancer\n                      , http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx (2020, accessed 12 July 2020)."},{"key":"bibr2-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw027"},{"key":"bibr3-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"bibr4-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1804754"},{"key":"bibr5-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29869"},{"key":"bibr6-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2012.01.006"},{"key":"bibr7-00494755211029782","first-page":"1","volume":"4","author":"Menon MP","year":"2018","journal-title":"J Glob Oncol"},{"key":"bibr8-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0613"},{"key":"bibr9-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2016.1127156"},{"key":"bibr10-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13403"},{"key":"bibr11-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28661"},{"key":"bibr12-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2001.00707.x"},{"key":"bibr13-00494755211029782","unstructured":"International Agency for Research on Cancers. International Incidence of childhood cancer 3.\n                      Int Agency Res Cancers\n                      , https:\/\/iicc.iarc.fr\/includes\/results\/registries\/Africa\/Africa_UGANDA_Kampala.pdf (2020, accessed 2 July 2020)."},{"key":"bibr14-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-75"},{"key":"bibr15-00494755211029782","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11575"},{"key":"bibr16-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.07.001"},{"key":"bibr17-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-4-375"},{"key":"bibr18-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09027.x"},{"key":"bibr19-00494755211029782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08143.x"},{"key":"bibr20-00494755211029782","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.12.3610"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755211029782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755211029782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755211029782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:33:32Z","timestamp":1777642412000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755211029782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/00494755211029782"],"URL":"https:\/\/doi.org\/10.1177\/00494755211029782","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]}}}