{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:30:41Z","timestamp":1780486241762,"version":"3.54.1"},"reference-count":5,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Congenital syphilis occurs due to trans-placental transmission of Treponema pallidum or rarely, intrapartum contact with infectious lesions. Even though preventable, congenital syphilis occurs sporadically in India, owing to lack of antenatal screening as well as the lack of awareness among clinicians about the burden of syphilis in the community. Since a significant overlap of clinical manifestations exists with many systemic diseases, awareness among clinicians is crucial for an early diagnosis. Renomegaly, nephrotic syndrome and nephritis can all be the signs of renal involvement in congenital syphilis, which can provide clues of the diagnosis. Direct invasion by spirochetes, hypersensitivity reactions and immune complex deposition in glomeruli contribute to the pathogenesis. We report a case of congenital syphilis characterised by delayed diagnosis with renal as well as cutaneous manifestations from missed maternal syphilis during the antenatal period and owing to the lack of antenatal screening.<\/jats:p>","DOI":"10.1177\/00494755211041297","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T09:27:59Z","timestamp":1630142879000},"page":"202-204","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Congenital syphilis: Need for intensification of antenatal screening and clinician awareness"],"prefix":"10.1177","volume":"52","author":[{"given":"Minu P","family":"Sunny","sequence":"first","affiliation":[{"name":"Junior Resident, Department of Pediatrics, Government Medical College Kozhikode, Kozhikode, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-6692","authenticated-orcid":false,"given":"C","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Additional Professor, Department of Pediatrics, Government Medical College Kozhikode, Kozhikode, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PR Sabeel","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Pediatrics, Government Medical College Kozhikode, Kozhikode, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-455X","authenticated-orcid":false,"given":"MG","family":"Geeta","sequence":"additional","affiliation":[{"name":"Professor, Department of Pediatrics, Government Medical College Kozhikode, Kozhikode, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"bibr1-00494755211041297","doi-asserted-by":"crossref","first-page":"e0211720","DOI":"10.1371\/journal.pone.0211720","volume":"14","author":"Korenromp EL","year":"2019","journal-title":"PLoS One"},{"key":"bibr2-00494755211041297","unstructured":"The National Strategy and Operational Guidelines towards Elimination of Congenital Syphilis, 2015 published by NACO under Ministry of Health and Family Welfare and WHO."},{"key":"bibr3-00494755211041297","unstructured":"WHO.\n                      Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV and syphilis\n                      . Geneva: World Health Organization, 2019, www.who.int\/reproductive health\/publications\/emtct-hiv-syphilis\/en (accessed 13 August 2021)."},{"key":"bibr4-00494755211041297","unstructured":"WHO.\n                      Report on global sexually transmitted infection surveillance 2018\n                      . Geneva: World Health Organization, 2019. https:\/\/www.who.int\/reproductive health\/publications\/stis-surveillance-2018\/en (accessed 13 August 2021)."},{"key":"bibr5-00494755211041297","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2005.06.005"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755211041297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755211041297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755211041297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:33:44Z","timestamp":1777642424000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755211041297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,28]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/00494755211041297"],"URL":"https:\/\/doi.org\/10.1177\/00494755211041297","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,28]]}}}