{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:11:03Z","timestamp":1777907463323,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>In this prospective study, children from 1-month to 12-years, admitted with positive IgM ELISA testing for scrub typhus, were enrolled over 1-year and administered an empirical single dose of azithromycin (10\u2005mg\/kg). All 189 (median age 4.84-years) children had fever with median duration of 8 days at admission. Shortness of breath, altered sensorium, headache, lymphadenopathy, hepatosplenomegaly, pallor, oedema and hypotension were the most prominent symptoms\/signs. About 46% of children developed complications, among them hepatic, neurological and cardiovascular were most common. Our study showed a remarkable response to azithromycin, with mean defervescence of 32\u2005h and no mortality. The presence of shortness of breath, headache, altered sensorium, hepatosplenomegaly, meningeal signs, severe anemia, leucocytosis, hyponatremia along with\/without any of above mentioned three systemic complications were independent predictors for delayed treatment response by multivariate logistic regression analysis. Hepatic, neurological and cardiovascular complications are an emerging trend. Empiric azithromycin based on clinical suspicion of scrub typhus can be lifesaving.<\/jats:p>","DOI":"10.1177\/00494755221081595","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T04:17:45Z","timestamp":1648527465000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical profile and predictors of therapeutic outcome with azithromycin in pediatric scrub typhus: A study from Eastern India"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-1080","authenticated-orcid":false,"given":"Arindam","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Midnapore Medical College, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-7627","authenticated-orcid":false,"given":"Pranab Kumar","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, R.G Kar Medical College, West Bengal, India. Previous affiliation (when the work was done): Associate Professor, Department of Paediatrics, Midnapore Medical College, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil Kumar","family":"Hemram","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Midnapore Medical College, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghna","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Statistician cum Tutor, IPGMER & SSKM Hospital, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Midnapore Medical College, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"bibr1-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060634"},{"key":"bibr2-00494755221081595","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0056"},{"key":"bibr3-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3143-9"},{"key":"bibr4-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-016-2171-6"},{"key":"bibr5-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2011.11.001"},{"key":"bibr6-00494755221081595","first-page":"24","volume":"58","author":"Vivekanandan M","year":"2010","journal-title":"J Assoc Physicians India"},{"key":"bibr7-00494755221081595","first-page":"CD002150","volume":"2","author":"Panpanich R","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr8-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002150.pub2"},{"key":"bibr9-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-017-1035-0"},{"key":"bibr10-00494755221081595","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.159279"},{"key":"bibr11-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00508-07"},{"key":"bibr12-00494755221081595","unstructured":"Government of West Bengal: Integrated Disease Surveillance Programme (IDSP)- Protocol for empirical antibiotic and testing for Scrub Typhus. Available from: https:\/\/www.wbhealth.gov.in\/uploaded_files\/IDSP\/Protocol_for_empirical_antibiotic_testing_Scrub_Typhus_(03.12_.2019)_.pdf."},{"key":"bibr13-00494755221081595","unstructured":"Government of West Bengal: Integrated Disease Surveillance Programme (IDSP)- Guideline for testing Scrub Typhus in Acute Fever. Available from: https:\/\/www.wbhealth.gov.in\/uploaded_files\/IDSP\/Scrub_Typhus_Guideline_for_testing_in_Acute_Fever_(2019).pdf."},{"key":"bibr14-00494755221081595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO)","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"bibr15-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000350"},{"key":"bibr16-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-010-0024-3"},{"key":"bibr17-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmab013"},{"key":"bibr18-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmab087"},{"key":"bibr19-00494755221081595","doi-asserted-by":"publisher","DOI":"10.33314\/jnhrc.v18i2.2730"},{"key":"bibr20-00494755221081595","first-page":"526","volume":"25","author":"Feng X","year":"2009","journal-title":"J Pract Med"},{"key":"bibr21-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1086\/425008"},{"key":"bibr22-00494755221081595","first-page":"756","volume":"98","author":"Chanta C","year":"2015","journal-title":"J Med Assoc Thai"},{"key":"bibr23-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trx066"},{"key":"bibr24-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.14487"},{"key":"bibr25-00494755221081595","first-page":"74","volume":"74","author":"Phuklia W","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"bibr26-00494755221081595","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.10.005"},{"key":"bibr27-00494755221081595","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.67.497"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755221081595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755221081595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755221081595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:34:24Z","timestamp":1777642464000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755221081595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/00494755221081595"],"URL":"https:\/\/doi.org\/10.1177\/00494755221081595","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]}}}