{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:11:13Z","timestamp":1777907473928,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Glucose 6 Phosphate Dehydrogenase (G6PD) enzyme activity estimation in a freshly collected blood sample is the most widely used diagnostic method for the diagnosis of G6PD deficiency. The objective is to evaluate the need for newborn screening for G6PD deficiency over post-malarial diagnosis and the feasibility and reliability of using dried blood spots (DBS) as samples for screening. A total of 562 samples were analyzed for G6PD and parallel measurement of G6PD activity by the colorimetric method in whole blood and DBS was carried out in the neonatal subset. Among 466 adults, 27 (5.7%) showed G6PD deficiency, out of whom 22 (81.48%) were diagnosed after the malarial encounter. In the pediatric group, 8 neonates showed G6PD deficiency. G6PD activity estimated from DBS samples agreed with whole blood, with a statistically significant strong positive correlation. Screening of G6PD deficiency at birth to prevent future unwarranted complications, using DBS is feasible.<\/jats:p>","DOI":"10.1177\/00494755221125615","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T11:19:51Z","timestamp":1663067991000},"page":"100-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Glucose 6 phosphate dehydrogenase deficiency quantitative test in dried blood spot\u2013 a potential marker for adult unknown G6PD deficiency"],"prefix":"10.1177","volume":"53","author":[{"given":"Prajna P.","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Srinivas Institute of Medical Sciences and Research Centre, Mukka, Mangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-9661","authenticated-orcid":false,"given":"Vijetha Shenoy","family":"Belle","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monalisa","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00087"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000343123"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.2009.953828"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006230"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002224"},{"key":"e_1_3_2_8_2","first-page":"424","article-title":"Evaluation of neonatal indirect hyperbilirubinaemia at zanjan province of Iran in 2001-2003: prevalence of glucose-6-phosphate dehydrogenase deficiency","volume":"48","author":"Koosha A","year":"2007","unstructured":"Koosha A, Rafizadeh B. 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