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Management is usually supportive, and the role of chelation therapy has not been established. Copper is not dialysable. Plasmapheresis has been shown to remove protein-bound copper, reducing plasma and intracellular concentrations. We present a case of severe copper sulphate poisoning, who did not improve with chelation therapy with D-penicillamine and supportive care, but with therapeutic plasma exchange (four cycles) showed rapid clinical recovery.<\/jats:p>","DOI":"10.1177\/00494755231151256","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T02:24:31Z","timestamp":1673403871000},"page":"327-328","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe copper sulphate poisoning: A case rescued with plasmapheresis"],"prefix":"10.1177","volume":"53","author":[{"given":"Jandhyala Anand","family":"Shankar","sequence":"first","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anterpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshay","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Selvam","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Hans","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-3478","authenticated-orcid":false,"given":"Ashok Kumar","family":"Pannu","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.660572"},{"key":"e_1_3_2_3_2","first-page":"77","article-title":"Greenish-blue gastric content: literature review and case report on acute copper sulfate poisoning","volume":"29","author":"Nastoulis E","year":"2017","unstructured":"Nastoulis E, Karakasi MV, Couvaris CM, et al. 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