{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:09:46Z","timestamp":1777907386213,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Hepatitis C virus (HCV) infection has varied clinical manifestations. Noninvasive tools can be useful to assess the severity of liver disease and the rate of spontaneous clearance. HCV infection was determined by antibody or RNA-based tests over a period of 18 months in 8030 samples from the Gastroenterology department. Noninvasive indicators (AST-to-platelet ratio index and fibrosis-4 index) were computed. HCV RNA load was compared with Child\u2013Turcotte\u2013Pugh score. Rate of spontaneous clearance was estimated. About 3.2% of patients were found to have HCV. Fatigue, anorexia, and nausea were the primary complaints followed by ascites and encephalopathy. Extrahepatic features such as autoimmune hepatitis and non-Hodgkin's lymphoma were rare. There was an absence of advanced liver cirrhosis (\u03ba = 0.96) in the majority of cases. Spontaneous HCV resolution was seen in 10.37%.<\/jats:p>","DOI":"10.1177\/00494755231177325","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T06:47:47Z","timestamp":1687416467000},"page":"444-447","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A study on the clinical spectrum of Hepatitis C virus infection from a tertiary care center in Sub-Himalayan India\u2014spontaneous clearance, a neglected phenomenon"],"prefix":"10.1177","volume":"53","author":[{"given":"Kuhu","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Senior Resident of Microbiology, Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5609-7492","authenticated-orcid":false,"given":"Deepjyoti","family":"Kalita","sequence":"additional","affiliation":[{"name":"Senior Resident of Microbiology, Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balram Ji","family":"Omar","sequence":"additional","affiliation":[{"name":"Professor, Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Additional Professor Department of Gastroenterology, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratima","family":"Gupta","sequence":"additional","affiliation":[{"name":"Professor & Head, Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"bibr1-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1038\/333195a0"},{"key":"bibr2-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1126\/science.2523562"},{"key":"bibr3-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"bibr4-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"bibr5-00494755231177325","unstructured":"Child CG and Turcotte JG. Surgery and portal hypertension.\n                      Major Probl Clin Surg\n                      1964; 1: 1\u201385."},{"key":"bibr6-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"bibr7-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.07.003"},{"key":"bibr8-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.07.013"},{"key":"bibr9-00494755231177325","doi-asserted-by":"publisher","DOI":"10.4066\/AMJ.2014.1883"},{"key":"bibr10-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9708-x"},{"key":"bibr11-00494755231177325","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2002.00364.x"},{"key":"bibr12-00494755231177325","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C Work Group. KDIGO 2018 Clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of Hepatitis C in chronic kidney disease. 2018."}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755231177325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755231177325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755231177325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:35:34Z","timestamp":1777642534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755231177325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/00494755231177325"],"URL":"https:\/\/doi.org\/10.1177\/00494755231177325","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}