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Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in ALA patients compared to controls and further reduced in complicated cases. HDL-C emerged as an independent predictor of complicated ALA and demonstrated better predictive value than conventional inflammatory markers such as total leucocyte count and C-reactive protein. Lower HDL-C levels were also linked to an increased need for percutaneous catheter drainage and longer hospital stay. Post-treatment assessments showed significant improvement in HDL-C levels. These findings suggest that HDL-C is a valuable, low-cost biomarker for assessing ALA severity and guiding clinical decisions, especially in resource-limited settings.<\/jats:p>","DOI":"10.1177\/00494755251374469","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T13:01:56Z","timestamp":1756818116000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-density lipoprotein cholesterol at admission reflects disease course, severity, and influences management decisions in patients with amoebic liver abscess"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-4865","authenticated-orcid":false,"given":"Ramesh","family":"Kumar","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-0190","authenticated-orcid":false,"given":"Jinit R","family":"Soni","sequence":"additional","affiliation":[{"name":"Senior Resident, Department of Gastroenterology, All India Institute of Medical\rSciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7061-4433","authenticated-orcid":false,"given":"Rishabh","family":"Patel","sequence":"additional","affiliation":[{"name":"Post DM, Department of Gastroenterology, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-3563","authenticated-orcid":false,"given":"Tanmoy","family":"Maji","sequence":"additional","affiliation":[{"name":"Post DM, Department of Gastroenterology, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-1382","authenticated-orcid":false,"given":"Sudhir","family":"Kumar","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-8910","authenticated-orcid":false,"given":"Rajeev N","family":"Priyadarshi","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"545","article-title":"Pathogenicity of Entamoeba histolytica \u2013 effect of cholesterol on the virulence of strains of amoebae","volume":"67","author":"Vinayak VK","year":"1978","unstructured":"Vinayak VK, Chakravarti RN, Agarwal KC, et al. 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