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Results showed a general decline in TB mortality, with average annual reductions of \u22122.3% in men and \u22121.9% in women. Brazil, Colombia, and Canada exhibited continuous decreases, while Saint Lucia, Jamaica, and Honduras had episodes of increase or fluctuation. The highest mortality rates persisted in Bolivia, Mexico, Nicaragua, Honduras, and Peru. Regional analyses indicated periods of trend stabilisation, especially in Central and South America during the latter years. Despite overall progress, significant disparities by region and sex remain, reflecting complex social, economic, and healthcare factors. 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