{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:58:37Z","timestamp":1782853117314,"version":"3.54.5"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Acute kidney injury (AKI) is a frequent and severe complication of acute pancreatitis (AP) associated with high mortality. We retrospectively analysed 129 patients with AP admitted over 10 years to a tertiary hospital. AKI occurred in 53.5% and was linked to greater mortality (37.7% vs. 11.7%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Compared with non-AKI patients, those with AKI had higher white cell counts and more severe metabolic derangements, including acidosis, hypoalbuminaemia, and electrolyte abnormalities. On multivariable analysis, elevated white cell count, lower serum bicarbonate, and lower systolic blood pressure independently predicted the development of AKI. Among AKI patients, non-survivors showed more profound metabolic derangement and haemodynamic instability. Simple bedside parameters\u2014leucocytosis, metabolic acidosis, hypoalbuminaemia, and hypotension\u2014predicted both AKI and mortality. Early identification and correction of these abnormalities may prevent renal injury and improve survival in AP.\n                  <\/jats:p>","DOI":"10.1177\/00494755261424984","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:50:44Z","timestamp":1771609844000},"page":"466-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and biochemical predictors of acute kidney injury and mortality in acute pancreatitis: Experience from a tertiary hospital in south India"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2669-9659","authenticated-orcid":false,"given":"Thotanolla Surya","family":"Prakash","sequence":"first","affiliation":[{"name":"Sri Venkateswara Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7661-1326","authenticated-orcid":false,"given":"Namesh","family":"Kamat","sequence":"additional","affiliation":[{"name":"Sri Venkateswara Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6446-3033","authenticated-orcid":false,"given":"Jeeja Jaya","family":"Janardhanan","sequence":"additional","affiliation":[{"name":"Sri Venkateswara Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.218"},{"key":"e_1_3_3_3_2","first-page":"845","article-title":"Acute kidney injury in acute pancreatitis: Pathophysiology and clinical outcomes","volume":"22","author":"Kumar R","year":"2022","unstructured":"Kumar R, Sharma V, Singh H, et al. Acute kidney injury in acute pancreatitis: Pathophysiology and clinical outcomes. Pancreatology 2022; 22: 845\u2013853.","journal-title":"Pancreatology"},{"key":"e_1_3_3_4_2","first-page":"39","article-title":"Acute renal failure in severe pancreatitis: A population-based study","volume":"7","author":"Lin HY","year":"2018","unstructured":"Lin HY, Lai JI, Lai YC, et al. Acute renal failure in severe pancreatitis: A population-based study. J Clin Med 2018; 7: 39.","journal-title":"J Clin Med"},{"key":"e_1_3_3_5_2","first-page":"143","article-title":"Pathophysiology of acute kidney injury in severe acute pancreatitis","volume":"320","author":"Meduri GU","year":"2000","unstructured":"Meduri GU, Chinn AJ, Leeper KV, et al. Pathophysiology of acute kidney injury in severe acute pancreatitis. Am J Med Sci 2000; 320: 143\u2013149.","journal-title":"Am J Med Sci"},{"key":"e_1_3_3_6_2","first-page":"1316","article-title":"Early prediction of mortality in acute pancreatitis","volume":"103","author":"Wu BU","year":"2008","unstructured":"Wu BU, Johannes RS, Sun X, et al. Early prediction of mortality in acute pancreatitis. Am J Gastroenterol 2008; 103: 1316\u20131321.","journal-title":"Am J Gastroenterol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1626664"},{"key":"e_1_3_3_8_2","first-page":"123","article-title":"Acute kidney injury in severe acute pancreatitis: Incidence, risk factors, and outcome","volume":"24","author":"Kumar A","year":"2019","unstructured":"Kumar A, Sinha S, Arora A, et al. Acute kidney injury in severe acute pancreatitis: Incidence, risk factors, and outcome. Nephrology (Carlton) 2019; 24: 123\u2013129.","journal-title":"Nephrology (Carlton)"},{"key":"e_1_3_3_9_2","first-page":"1503","article-title":"Acute pancreatitis-induced kidney injury: Inflammatory and metabolic interplay","volume":"6","author":"Raman M","year":"2021","unstructured":"Raman M, Atta MG. Acute pancreatitis-induced kidney injury: Inflammatory and metabolic interplay. Kidney Int Rep 2021; 6: 1503\u20131210.","journal-title":"Kidney Int Rep"},{"key":"e_1_3_3_10_2","first-page":"816","article-title":"Inflammation and renal injury in critical illness","volume":"80","author":"Prowle JR","year":"2011","unstructured":"Prowle JR, Molan MP, Hornsey E, et al. Inflammation and renal injury in critical illness. Kidney Int 2011; 80: 816\u2013822.","journal-title":"Kidney Int"},{"key":"e_1_3_3_11_2","first-page":"1958","article-title":"Hypoalbuminaemia and acute kidney injury: A meta-analysis","volume":"38","author":"Wiedermann CJ","year":"2010","unstructured":"Wiedermann CJ, Wiedermann W, Joannidis M. Hypoalbuminaemia and acute kidney injury: A meta-analysis. Crit Care Med 2010; 38: 1958\u20131965.","journal-title":"Crit Care Med"},{"key":"e_1_3_3_12_2","first-page":"715","article-title":"Early systemic inflammatory response syndrome is associated with organ failure and death in acute pancreatitis","volume":"18","author":"Singh N","year":"2018","unstructured":"Singh N, Sharma B, Sharma M, et al. Early systemic inflammatory response syndrome is associated with organ failure and death in acute pancreatitis. Pancreatology 2018; 18: 715\u2013720.","journal-title":"Pancreatology"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755261424984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755261424984","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755261424984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:58:23Z","timestamp":1782849503000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755261424984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/00494755261424984"],"URL":"https:\/\/doi.org\/10.1177\/00494755261424984","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]}}}