{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:52:44Z","timestamp":1782852764429,"version":"3.54.5"},"reference-count":5,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Urosepsis is a severe complication of urinary tract infections (UTIs) and is increasingly driven by multidrug-resistant (MDR) organisms, posing major therapeutic challenges, particularly in regions with a high UTI burden. This observational study reports 41 microbiologically confirmed urosepsis cases over 1.5 years from Western India, where climatic factors and the prevalence of urolithiasis predispose to complicated UTIs. High resistance rates were noted to fluoroquinolones, cotrimoxazole, and third-generation cephalosporins, while nitrofurantoin showed retained activity in 78.0%. These findings highlight the escalating threat of MDR pathogens in urosepsis and underscore the need for local antimicrobial stewardship and continued surveillance to guide empirical therapy.<\/jats:p>","DOI":"10.1177\/00494755261425321","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:11:52Z","timestamp":1771870312000},"page":"593-594","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging menace of multidrug-resistant organisms in urosepsis: Observations from western India"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5696-6133","authenticated-orcid":false,"given":"Shikhir","family":"Malhotra","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1346-7481","authenticated-orcid":false,"given":"Vibhor","family":"Tak","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-3565","authenticated-orcid":false,"given":"Deepak","family":"Kumar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Jodphur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Choudhary","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Jodhpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Choudhary","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Jodhpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal Krishana","family":"Bohra","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Jodphur"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13100925"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/life14010106"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmmb.2024.100647"},{"key":"e_1_3_2_5_2","first-page":"235","article-title":"Antimicrobial resistance trends in urinary tract infection at secondary care centres in central India: carbepenem resistance crossing 20% in community","volume":"7","author":"Vyas A","year":"2023","unstructured":"Vyas A, Karuna T, Kumar S, et al. Antimicrobial resistance trends in urinary tract infection at secondary care centres in central India: carbepenem resistance crossing 20% in community. 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