{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:02:30Z","timestamp":1789776150264,"version":"4.0.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>Despite available guidelines, congenital syphilis (CS) continues to burden low- and middle-income countries (LMICs), with failures occurring across multiple points. Two prior case reports from India described symptomatic infants with delayed diagnoses resulting from absent or ignored antenatal screening. We add five neonates identified prospectively at birth at a tertiary care centre in northern India (September 2024\u2013January 2026), born to mothers with reactive syphilis serology. All were asymptomatic, but maternal treatment was adequate in only two cases. Neonatal RPR was reactive in one infant only. Based on CDC criteria, one neonate was classified as highly probable CS, three as possible, and one as less likely. Limited availability of aqueous crystalline penicillin necessitated benzathine penicillin use in all cases, and one infant left against medical advice. Together, these series map recurring, correctable failures across the entire CS prevention cascade in LMICs.<\/jats:p>","DOI":"10.1177\/00494755261455658","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:37:20Z","timestamp":1780069040000},"page":"730-732","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Congenital syphilis in neonates: Persistent diagnostic and treatment challenges in resource-limited settings"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7059-921X","authenticated-orcid":false,"given":"Anjali","family":"Joshi","sequence":"first","affiliation":[{"name":"AIIMS Bilaspur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeetinder","family":"Joshi","sequence":"additional","affiliation":[{"name":"Senior Resident, Directorate of Elementary Education, Government of Haryana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pothapregada","family":"Sriram","sequence":"additional","affiliation":[{"name":"AIIMS Bilaspur"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/00494755211041297"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/00494755251325318"},{"key":"e_1_3_2_4_2","first-page":"12","article-title":"Biological false-positive results for syphilis in pregnant women","volume":"40","author":"Tognon F","year":"2018","unstructured":"Tognon F, Pinotti MF, Ferraz L, et al. Biological false-positive results for syphilis in pregnant women. Rev Bras Ginecol Obstet 2018; 40: 12\u201317.","journal-title":"Rev Bras Ginecol Obstet"},{"key":"e_1_3_2_5_2","volume-title":"WHO guideline on syphilis screening and treatment for pregnant women","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. WHO guideline on syphilis screening and treatment for pregnant women. Geneva: WHO, 2017."},{"key":"e_1_3_2_6_2","first-page":"524","volume-title":"Remington and Klein's infectious diseases of the fetus and newborn infant","author":"Dobson SR","year":"2016","unstructured":"Dobson SR, Sanchez PJ. Syphilis. In: Remington and Klein's infectious diseases of the fetus and newborn infant. 8th ed. Philadelphia: Elsevier, 2016, pp.524\u2013562.","edition":"8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012684"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7004a1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002473"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181ac8a69"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755261455658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755261455658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755261455658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:20:17Z","timestamp":1789773617000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755261455658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/00494755261455658"],"URL":"https:\/\/doi.org\/10.1177\/00494755261455658","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}