{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:02:04Z","timestamp":1789786924612,"version":"4.0.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>Neonatal candidaemia is a significant cause of morbidity and mortality in neonatal intensive care settings, particularly in low- and middle-income countries where diagnostic delays remain a challenge.<\/jats:p>\n                  <jats:p>\n                    The diagnostic utility of a five-parameter sepsis screen and the comparison of matrix-assisted laser desorption ionisation-time of flight mass spectrometry (MALDI-TOF MS) with VITEK-2 for identification of\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species in neonates were evaluated at a tertiary care institute in the sub-Himalayan region of India from November 2022 to March 2024.\n                    <jats:italic toggle=\"yes\">Non-albicans Candida<\/jats:italic>\n                    species accounted for 75% of isolates. Significant discordance was observed between MALDI-TOF MS and VITEK-2, particularly for cryptic species. The sepsis screen demonstrated a sensitivity of 77.8% but lacked specificity because it included only culture-positive fungal cases. The mortality rate was 30%. Thus, we conclude that a sepsis screen serves as a useful early screening tool but is non-specific. MALDI-TOF MS provides more accurate and faster species identification than biochemical methods. A combined diagnostic approach may help reduce delays in targeted therapy in neonatal candidemia.\n                  <\/jats:p>","DOI":"10.1177\/00494755261467569","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:25:20Z","timestamp":1783502720000},"page":"632-636","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of sepsis screening and matrix-assisted laser desorption ionisation-time of flight mass spectrometry for the diagnosis of neonatal candidaemia in a Sub-Himalayan tertiary centre in India"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6131-4907","authenticated-orcid":false,"given":"Arushi","family":"Gupta","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-2730","authenticated-orcid":false,"given":"Balram Ji","family":"Omar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-8702","authenticated-orcid":false,"given":"Mohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"VMMC and Safdarjung Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogendra Pratap","family":"Mathuria","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5048-4849","authenticated-orcid":false,"given":"Sriparna","family":"Basu","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.01.053"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-025-01952-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.118919"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/09732179241277635"},{"key":"e_1_3_2_6_2","first-page":"111","article-title":"Automated detection and antifungal susceptibility profile of Candida species isolated from blood cultures of neonatal ICU patients using MALDI-TOF and VITEK: insights from a tertiary care center in Rajasthan","volume":"6","author":"Sharma R","year":"2024","unstructured":"Sharma R, Purohit S, Lamba M, et al. Automated detection and antifungal susceptibility profile of Candida species isolated from blood cultures of neonatal ICU patients using MALDI-TOF and VITEK: insights from a tertiary care center in Rajasthan. Pediatr Infect Dis 2024; 6: 111\u2013114. doi: https:\/\/doi.org\/10.5005\/jp-journals-10081-1442.","journal-title":"Pediatr Infect Dis"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/813871"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02088-12"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.3.638-680.2004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(12)70004-X"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114834"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.632679"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01045-12"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0056-z"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2018.701.290"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318256905c"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.25083\/rbl\/25.5\/1892.1898"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.35.1.99"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20243473"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01749-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1586\/epr.13.8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1875041901104010004","article-title":"Pediatric sepsis - part I: \u2018Children are not small adults!\u2019","volume":"4","author":"Wheeler DS","year":"2011","unstructured":"Wheeler DS, Wong HR, Zingarelli B. Pediatric sepsis - part I: \u2018Children are not small adults!\u2019. Open Inflamm J 2011; 4: 4\u201315.","journal-title":"Open Inflamm J"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myad010"},{"key":"e_1_3_2_24_2","article-title":"Trends and characteristics of candidemia in patients with suspected sepsis: a two-year retrospective study from a tertiary hospital in Uttarakhand","volume":"17","author":"Singh R","year":"2025","unstructured":"Singh R, Kakati B, Mittal G. Trends and characteristics of candidemia in patients with suspected sepsis: a two-year retrospective study from a tertiary hospital in Uttarakhand. 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