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Evidence regarding extracorporeal blood purification therapy, including haemoperfusion and therapeutic plasma exchange, remains limited, particularly in resource-limited settings. We report a familial cluster of four patients, representing a markedly delayed presentation. They demonstrated markedly heterogeneous clinical outcomes ranging from minimal biochemical abnormalities to fatal acute liver failure.<\/jats:p>","DOI":"10.1177\/00494755261473043","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:22:45Z","timestamp":1785331365000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed presentation of familial amatoxin mushroom poisoning with markedly heterogeneous outcomes treated with haemoperfusion and plasma exchange: A case series from Vietnam"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6648-8503","authenticated-orcid":false,"given":"Nguyen Dang","family":"Duc","sequence":"first","affiliation":[{"name":"Bach Mai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Tien","family":"Dat","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam Nguyen Hong","family":"Khanh","sequence":"additional","affiliation":[{"name":"Vinh University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.09.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(97)00074-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000153531.69448.49"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.10.013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120014646"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/487480"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110361758"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.08.018"},{"key":"e_1_3_2_10_2","first-page":"455","article-title":"Liver transplantation and artificial liver support in acute liver failure","volume":"20","author":"Mao SA","year":"2016","unstructured":"Mao SA, Glorioso JM, Nyberg SL. 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