{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:12:19Z","timestamp":1786119139677,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"abstract":"<jats:p>\n                    Beh\u00e7et's disease (BD) is a multi-system inflammatory disorder characterised by recurrent oral, genital or ocular inflammation, and may present with variable-vessel vasculitis.\n                    <jats:sup>\n                      <jats:xref ref-type=\"bibr\">1<\/jats:xref>\n                    <\/jats:sup>\n                    It has a distinctive geographic distribution, with the highest prevalence along the historic Silk Road, particularly in Turkey and Iran.\n                    <jats:sup>\n                      <jats:xref ref-type=\"bibr\">2<\/jats:xref>\n                      <jats:xref ref-type=\"bibr\"\/>\n                      \u2013\n                      <jats:xref ref-type=\"bibr\">4<\/jats:xref>\n                    <\/jats:sup>\n                    In contrast, BD is considered rare in India, with limited epidemiological data and predominantly hospital-based series.\n                    <jats:sup>\n                      <jats:xref ref-type=\"bibr\">5<\/jats:xref>\n                      ,\n                      <jats:xref ref-type=\"bibr\">6<\/jats:xref>\n                    <\/jats:sup>\n                    Although recurrent oral ulcers are nearly universal, systemic manifestations, including ocular, vascular, neurological and gastrointestinal involvement, vary across regions.\n                    <jats:sup>\n                      <jats:xref ref-type=\"bibr\">2<\/jats:xref>\n                      ,\n                      <jats:xref ref-type=\"bibr\">3<\/jats:xref>\n                    <\/jats:sup>\n                    Fever is not a classic presenting symptom in mucocutaneous disease, but may occur in vascular or neuro-Beh\u00e7et's, where it reflects heightened systemic inflammatory activity.\n                    <jats:sup>\n                      <jats:xref ref-type=\"bibr\">7<\/jats:xref>\n                    <\/jats:sup>\n                    Consequently, BD may masquerade as a prolonged febrile illness, particularly before characteristic features emerge. Atypical presentations may delay diagnosis, particularly in low-prevalence regions.\n                  <\/jats:p>","DOI":"10.1177\/00494755261474031","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:49:51Z","timestamp":1785862191000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged fever with erythema nodosum-like lesions: Beh\u00e7et's disease as a diagnostic challenge in a tropical low-prevalence setting"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-0999","authenticated-orcid":false,"given":"Prachee Ambarish","family":"Makashir","sequence":"first","affiliation":[{"name":"Professor, General Medicine, Bharati Vidyapeeth (Deemed to be University), Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1297-0379","authenticated-orcid":false,"given":"Ullas Chintamani","family":"Dwarakanath","sequence":"additional","affiliation":[{"name":"Senior Resident, General Medicine, Bharati Vidyapeeth (Deemed to be University), Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0427-8031","authenticated-orcid":false,"given":"Bryan Jacob","family":"Koithara","sequence":"additional","affiliation":[{"name":"Senior Resident, General Medicine, Bharati Vidyapeeth (Deemed to be University), Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.208"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213225"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1430-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-008-9273-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.107636"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.255.163"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.624795"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101906"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17195"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1349"},{"key":"e_1_3_3_13_2","first-page":"1078","article-title":"International study group for Beh\u00e7et\u2019s disease","volume":"335","author":"Criteria for diagnosis of Beh\u00e7et\u2019s disease","year":"1990","unstructured":"Criteria for diagnosis of Beh\u00e7et\u2019s disease. International study group for Beh\u00e7et\u2019s disease. Lancet 1990; 335: 1078\u20131080. PubMed.","journal-title":"Lancet"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-008-9273-8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.75516"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2019.18215"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131227"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05026-2"},{"key":"e_1_3_3_19_2","first-page":"22","article-title":"Alleles and Beh\u00e7et\u2019s disease in Chinese Han nationality","volume":"42","author":"Association between HLA-B51","year":"2009","unstructured":"Association between HLA-B51. Alleles and Beh\u00e7et\u2019s disease in Chinese Han nationality. Chin J Dermatol 2009; 42: 22\u201324. 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