{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:27:07Z","timestamp":1787401627939,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Trop Doct"],"abstract":"<jats:p>\n                    In this prospective observational study, we aimed to evaluate the incidence of\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    infection in gallstone disease and to assess its association with different types of gallstones and histopathological findings. It was conducted on 200 patients undergoing cholecystectomy.\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    detection was performed using the rapid urease test and histopathological examination. Cholesterol stones constituted 70% of cases, while pigment stones accounted for 30%. The overall incidence of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    infection was 38.5%. A significantly higher prevalence of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    was observed in cholesterol stones (45%) compared to pigment (23.3%). Chronic cholecystitis was present in 88.5%, and incidental carcinoma in situ was found in 2%, all associated with\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    positivity. Significant associations were observed between\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    status and stone type (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.05). Our study establishes a significant association between\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    infection and gallstone disease, particularly cholesterol stones, and a potential link with premalignant gallbladder conditions.\n                  <\/jats:p>","DOI":"10.1177\/00494755261480449","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:32:34Z","timestamp":1787153554000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective observational study of the relationship between\n                    <i>Helicobacter pylori<\/i>\n                    and symptomatic gallstone disease"],"prefix":"10.1177","author":[{"given":"Shahnawaz Ahmed","family":"Chowdhary","sequence":"first","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Kesh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukul","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-9668","authenticated-orcid":false,"given":"Shubhajeet","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Murtaza","family":"Aaqib","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Gorakhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.03.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20192938"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-023-03355-z"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.972777"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1697797"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1188487"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15755"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.202302023-15"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.22-056"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/643109"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20231733"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13879"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i47.4991"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.57239\/prn.26.03410053"},{"key":"e_1_3_2_18_2","unstructured":"Rathi A. A study of association of helicobacter pylori with gallstone diseases [Internet]. 2025 [cited 2026 May 14]. Available from: http:\/\/www.ijlbpr.com\/uploadfiles\/84vol14issue12pp486-490.20251223043758.pdf"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2017.4"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2023.tb00275.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-26710-9.00014-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2026.107194"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2011.00423.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030595"},{"key":"e_1_3_2_26_2","first-page":"165","article-title":"Helicobacter pylori associated gallbladder diseases and their progression to gallbladder cancer: a review","volume":"14","author":"Fatima N","year":"2025","unstructured":"Fatima N, Raza ST, Kumar V, et al. Helicobacter pylori associated gallbladder diseases and their progression to gallbladder cancer: a review. J Microbiol Infect Dis 2025; 14: 165.","journal-title":"J Microbiol Infect Dis"},{"key":"e_1_3_2_27_2","article-title":"Eradication therapy to prevent gastric cancer in Helicobacter pylori\u2013positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies","volume":"348","author":"Ford AC","year":"2025","unstructured":"Ford AC, Yuan Y, Park JY, et al. Eradication therapy to prevent gastric cancer in Helicobacter pylori\u2013positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies. Gastroenterology [Internet]. 2025; 348: g3174 [cited 2026 May 14]. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0016508525000411","journal-title":"Gastroenterology [Internet]"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755261480449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00494755261480449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00494755261480449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:18:23Z","timestamp":1787401103000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00494755261480449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":26,"alternative-id":["10.1177\/00494755261480449"],"URL":"https:\/\/doi.org\/10.1177\/00494755261480449","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"article-number":"00494755261480449"}}