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Conservative management of typhoid perforation, which was widely advocated after the introduction of chloramphenicol, appears to be associated with a substantially increased mortality compared to surgery, although randomized comparisons have never been conducted. Clinical, radiological and ultrasound examination assist in the diagnosis of perforation. After vigorous resuscitation, simple surgical closure of the perforation and abdominal irrigation will suffice for most cases. Antibiotics effective against S. typhi, coliforms and anaerobes are required.<\/jats:p>","DOI":"10.1177\/004947559102100405","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T10:29:26Z","timestamp":1484303366000},"page":"149-152","source":"Crossref","is-referenced-by-count":7,"title":["Management of Bowel Perforation in Typhoid Fever"],"prefix":"10.1177","volume":"21","author":[{"given":"John","family":"Richens","sequence":"first","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, Keppel St, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,10,1]]},"reference":[{"key":"bibr1-004947559102100405","doi-asserted-by":"crossref","unstructured":"Butler T, Knight J, Nath SK, Speelman P, Roy WK, Azad MAK. Typhoid fever complicated by intestinal perforation: a persisting fatal disease requiring surgical management. 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