{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:21:33Z","timestamp":1777908093267,"version":"3.51.4"},"reference-count":4,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trop Doct"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>A study of 41 clinically diagnosed cases of possible tropical splenomegaly syndrome (TSS) was undertaken in Mulago Hospital, Kampala, Uganda, to determine the appropriateness of liver ultrasonography in confirming a diagnosis of TSS. Definitive diagnosis of TSS was made on liver biopsy in 35 (85%) cases. Abdominal ultrasound showed that 30 of the confirmed cases of TSS had normal liver echo-texture and portal vein diameter, and five had abnormally increased liver echo-texture. The combination of massive splenomegaly and hepatomegaly, together with normal ultrasound features of the liver was highly suggestive of TSS. The sensitivity of this criterion was 86% and the specificity was 83%. This non-invasive approach to the diagnosis of TSS is associated with less hazards than liver biopsy, and a normal echogram could be used to make the diagnosis in over 80% of cases, in the field where histopathology may be lacking.<\/jats:p>","DOI":"10.1177\/004947559502500314","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T15:54:04Z","timestamp":1484236444000},"page":"128-130","source":"Crossref","is-referenced-by-count":4,"title":["Non-Invasive Diagnosis of Tropical Splenomegaly Syndrome"],"prefix":"10.1177","volume":"25","author":[{"given":"Mohamed","family":"El-Shazly","sequence":"first","affiliation":[{"name":"Makerere Medical School, Faculty of Medicine, Makerere University, PO Box, 7072, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D O","family":"Okello","sequence":"additional","affiliation":[{"name":"Makerere Medical School, Faculty of Medicine, Makerere University, PO Box, 7072, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Kawooya","sequence":"additional","affiliation":[{"name":"Makerere Medical School, Faculty of Medicine, Makerere University, PO Box, 7072, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"bibr1-004947559502500314","volume-title":"Tropical Gastroenterology","author":"Cook GC","year":"1980"},{"key":"bibr2-004947559502500314","first-page":"495","volume-title":"Liver and Biliary Diseases","author":"Willward-Sadler GH","year":"1985","edition":"2"},{"key":"bibr3-004947559502500314","first-page":"55376","volume-title":"Liver and Biliary disease","author":"Dewbury KC","year":"1985","edition":"2"},{"issue":"3","key":"bibr4-004947559502500314","first-page":"304","volume":"80","author":"Belli L","year":"1990","journal-title":"Radiol Med Torino"}],"container-title":["Tropical Doctor"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/004947559502500314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/004947559502500314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:56:13Z","timestamp":1777643773000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/004947559502500314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1177\/004947559502500314"],"URL":"https:\/\/doi.org\/10.1177\/004947559502500314","relation":{},"ISSN":["0049-4755","1758-1133"],"issn-type":[{"value":"0049-4755","type":"print"},{"value":"1758-1133","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}