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The heterogeneity in responses to adversity underscores the influence of protective factors in promoting coping behaviour. The current study investigates fortitude as a potential protective resource by examining the potential direct, mediating, and moderating roles of fortitude in the relationship between perceived vulnerability to disease, fear of COVID-19, and indices of psychological well-being. Participants ( n\u2009=\u2009355) were schoolteachers who completed the Perceived Vulnerability to Disease Questionnaire, Fear of COVID-19 Scale, Fortitude Questionnaire, UCLA Loneliness Scale, trait scale of the State-Trait Anxiety Inventory, Beck Hopelessness Scale, and the Center for Epidemiological Studies Depression Scale. Path analysis indicated that fortitude had a health-sustaining effect that was evident in its association with all indices of psychological well-being. Fortitude also mediated the relationship between perceived vulnerability to disease and depression, anxiety, and loneliness. In addition, fortitude moderated the relationship between fear of COVID-19 and depression. The significant moderating and mediating effects of fortitude on psychological outcomes support its potential for counterbalancing the negative mental health impacts of COVID-19. Interventions aimed at enhancing fortigenic appraisals of self and others may prove beneficial in promoting psychological well-being.<\/jats:p>","DOI":"10.1177\/00812463221137876","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T02:33:27Z","timestamp":1669602807000},"page":"250-264","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["From fear and vulnerability to fortitude: sustaining psychological well-being in the face of the COVID-19 pandemic"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-7486","authenticated-orcid":false,"given":"Anita","family":"Padmanabhanunni","sequence":"first","affiliation":[{"name":"Department of Psychology, University of the Western Cape, Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-6623","authenticated-orcid":false,"given":"Tyrone B","family":"Pretorius","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of the Western Cape, Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"bibr1-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-020-00270-8"},{"key":"bibr2-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-020-00316-x"},{"key":"bibr3-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/11.1.11"},{"key":"bibr4-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1177\/0013164402062004005"},{"key":"bibr5-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1037\/h0037562"},{"key":"bibr6-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1964"},{"key":"bibr7-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113100"},{"key":"bibr8-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2020.102307"},{"key":"bibr9-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2021.106422"},{"key":"bibr10-00812463221137876","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182010604"},{"key":"bibr11-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-021-00692-6"},{"key":"bibr12-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2020.110220"},{"key":"bibr13-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2009.05.001"},{"key":"bibr14-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-020-00458-y"},{"key":"bibr15-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.2274"},{"key":"bibr16-00812463221137876","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.674032"},{"key":"bibr17-00812463221137876","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2022.2108087"},{"key":"bibr18-00812463221137876","author":"Hayes A. 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