{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:47:30Z","timestamp":1777715250011,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Psychiatry Med"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Despite many women suffering from psychosis in their childbearing years, limited data exist about the use of atypical antipsychotic agents in pregnancy. Atypical antipsychotic agents are often used to treat bipolar disorder, instead of lithium or valproate because of the known teratogenicity of those agents. As well, atypical antipsychotics are often prescribed in anxiety disorders and depression. This study sought to describe pregnancy outcomes for women prescribed atypical antipsychotics during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective review included all cases treated by Auckland Maternal Mental Health services in which atypical antipsychotic agents were utilized during pregnancy over three years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the three years, 45 pregnant women were prescribed atypical antipsychotic agents, most commonly quetiapine or olanzapine. Two-fifths (40%) were diagnosed with bipolar disorder and almost one-third (31%) with a psychotic disorder. Two-thirds (64%) were prescribed multiple psychotropic medications during their pregnancy. Instrumental delivery rates were elevated at 38%. A minority (13%) of the women developed gestational diabetes mellitus. Although 7% of infants were born premature, all were born after 35 weeks. Two major malformations were noted, similar to baseline community rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This naturalistic study adds to the limited literature about treatment with atypical antipsychotic agents in pregnancy, though not adequately powered to detect small differences in malformations or obstetrical outcomes. It also highlights the myriad of indications for which pregnant women are prescribed atypical antipsychotics, and the multiple other risk factors seen in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0091217417696739","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T23:48:15Z","timestamp":1488844095000},"page":"521-533","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Atypical antipsychotic use and outcomes in an urban maternal mental health service"],"prefix":"10.1177","volume":"51","author":[{"given":"Susan","family":"Hatters Friedman","sequence":"first","affiliation":[{"name":"The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charmian","family":"Moller-Olsen","sequence":"additional","affiliation":[{"name":"Auckland District Health Board, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandni","family":"Prakash","sequence":"additional","affiliation":[{"name":"Auckland District Health Board, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"North","sequence":"additional","affiliation":[{"name":"The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"bibr1-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.12.007"},{"key":"bibr2-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001403"},{"key":"bibr3-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-014-0465-0"},{"key":"bibr4-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-013-0330-6"},{"key":"bibr5-0091217417696739","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.94649"},{"key":"bibr6-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.179"},{"key":"bibr7-0091217417696739","doi-asserted-by":"publisher","DOI":"10.3109\/00048670903487217"},{"key":"bibr8-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614522682"},{"key":"bibr9-0091217417696739","first-page":"10","volume":"12","author":"Friedman SH","year":"2013","journal-title":"Curr Psychiatry"},{"key":"bibr10-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1071\/HC15081"},{"key":"bibr11-0091217417696739","unstructured":"Moller-Olsen C, Friedman SH, Prakash C, et al. Characteristics and risk factors of pregnant women prescribed mood stabilizers and antipsychotic agents. Under editorial review."},{"key":"bibr12-0091217417696739","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.040"},{"key":"bibr13-0091217417696739","doi-asserted-by":"publisher","DOI":"10.5888\/pcd11.130415"},{"key":"bibr14-0091217417696739","unstructured":"New Zealand Ministry of Health (NZMOH) (2006) Maternity Snapshot 2003: Provisional data, www.health.govt.nz\/publication\/maternity-snapshot-2003-provisional-data (accessed 8 August 2016)."},{"key":"bibr15-0091217417696739","unstructured":"New Zealand Ministry of Health (NZMOH) (2012) New Zealand Maternity Clinical Indicators, 2012, www.health.govt.nz\/system\/files\/documents\/publications\/new-zealand-maternity-clinical-indicators-2012-oct14-v2.pdf (accessed 8 June 2016)."},{"key":"bibr16-0091217417696739","unstructured":"Craig ED, McDonald G, Adams J, et\u00a0al.\n                      The health of children and young people with chronic conditions and disabilities in New Zealand\n                      . Dunedin: New Zealand Child and Youth Epidemiology Service, University of Otago, 2011 [As cited in Oben GLM.\n                      Indicators for congenital anomalies in New Zealand\n                      . 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