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A small percentage of athletes have persistent symptoms that cause significant morbidity, some of whom are ultimately diagnosed with post-concussion syndrome. In these athletes, symptoms in the emotional domain can be more prolonged than other domains, with athletes reporting anxiety and depression months to years following injury. A prior personal or family history of pre-existing mood disorder or attention-deficit\/hyperactivity disorder increases the risk of a prolonged duration of symptoms. In this case series, we discuss two cases of post-concussion syndrome in adolescent athletes with a past personal or family history of attention-deficit\/hyperactivity disorder, anxiety, and depression treated by a combination of cognitive behavioral therapy and medication with ongoing persistent symptoms. There is increased need for mental health screening in all athletes to identify individuals at risk for post-concussion syndrome. Early identification of at-risk individuals allows the interdisciplinary care team to discuss expectations for the athlete and family regarding duration of symptoms.<\/jats:p>","DOI":"10.1177\/0091217418805208","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T12:07:45Z","timestamp":1539864465000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Post-concussion syndrome and pre-existing mood disorder: A case report"],"prefix":"10.1177","volume":"54","author":[{"given":"S","family":"Tucker Price","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Trident\/Medical University of South Carolina Family Medicine Residency Program, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei O","family":"DeCastro","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Medical 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