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Studies on the black cohosh\u2019s psychological effects are generally focused on the perimenopausal depression and anxiety; and, its effects have been considered to be affiliated with its serotonergic and dopaminergic activities. We report a patient presenting with acute onset mania associated with black cohosh use, probably due to its psychopharmacological activities on serotonergic and dopaminergic receptors. We suggest that black cohosh must be used cautiously in the patients with history of unipolar depression or bipolar disorder.<\/jats:p>","DOI":"10.1177\/0091217420961185","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T14:23:40Z","timestamp":1600698220000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Black cohosh associated mania in a patient with unipolar depression"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-8960","authenticated-orcid":false,"given":"Murat","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[{"name":"Psychiatry Department, Erenk\u00f6y Training and Research Hospital for Psychiatry and Neurological Diseases, University of Health Sciences, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fenur","family":"O\u011fuz","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Istanbul Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin Emrem","family":"Be\u015ftepe","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Erenk\u00f6y Training and Research Hospital for Psychiatry and Neurological Diseases, University of Health Sciences, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazife Gamze Usta","family":"Sa\u011flam","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Erenk\u00f6y Training and Research Hospital for Psychiatry and Neurological Diseases, University of Health Sciences, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Ergelen","sequence":"additional","affiliation":[{"name":"Psychiatry Department, Erenk\u00f6y Training and Research Hospital for Psychiatry and Neurological Diseases, University of Health Sciences, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"bibr1-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-002-0457-2"},{"key":"bibr2-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-7-13"},{"key":"bibr3-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1021\/jf062808u"},{"key":"bibr4-0091217420961185","first-page":"869","volume":"13","author":"Wanwimolruk S","year":"2014","journal-title":"EXCLI J"},{"key":"bibr5-0091217420961185","doi-asserted-by":"publisher","DOI":"10.2174\/157488610790936150"},{"key":"bibr6-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181b2abf2"},{"key":"bibr7-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000236934.43701.c5"},{"key":"bibr8-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr9-0091217420961185","first-page":"21","volume":"2008","author":"Ruhlen RL","year":"2008","journal-title":"Integr Med Insights"},{"key":"bibr10-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1021\/jf034264r"},{"key":"bibr11-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142499"},{"key":"bibr12-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0306-y"},{"key":"bibr13-0091217420961185","first-page":"70","volume":"21","author":"Dobkin RD","year":"2010","journal-title":"Ann Clin Psychiatry"},{"key":"bibr14-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1177\/0897190014544785"},{"key":"bibr15-0091217420961185","first-page":"1","volume":"55","author":"Riemma G","year":"2019","journal-title":"Med"},{"key":"bibr16-0091217420961185","first-page":"272","volume":"110","author":"Stubbs C","year":"2017","journal-title":"J Okla State Med Assoc"},{"key":"bibr17-0091217420961185","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12476"},{"key":"bibr18-0091217420961185","doi-asserted-by":"crossref","unstructured":"Leach MJ, Moore V. Black cohosh (\n                      Cimicifuga\n                      spp.) for menopausal symptoms.\n                      Cochrane Database Syst Rev\n                      . Epub ahead of print 12 September 2012. 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