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Case study data implies psychiatric and cognitive symptoms preceding the diagnosis. This single case report presents a 68-year-old male with suspected late-onset bipolar disorder, later found to have sporadic Creutzfeld Jakob Disease. The patient was treated with lithium for this purported bipolar disorder. Approximately 2\u2009years later, the patient met the Center for Disease Control (CDC) diagnostic criteria for prion disease following a rapid decline in cognition. This case provides an example of a medical mimic of bipolar disorder in the geriatric population.<\/jats:p>","DOI":"10.1177\/00912174211010529","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:45:11Z","timestamp":1618443911000},"page":"202-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying medical mimics for late-life mania: A case of prion disease"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-3031","authenticated-orcid":false,"given":"Amber L","family":"Cadick","sequence":"first","affiliation":[{"name":"Union Hospital Family Medicine Residency, Terre Haute, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M","family":"Ehresman","sequence":"additional","affiliation":[{"name":"Union Hospital Family Medicine Residency, Terre Haute, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A","family":"Jones","sequence":"additional","affiliation":[{"name":"Union Hospital Family Medicine Residency, Terre Haute, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"bibr1-00912174211010529","first-page":"51","volume":"27","author":"Freudenreich O.","year":"2012","journal-title":"Psychiatr Times"},{"key":"bibr2-00912174211010529","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2016.11.289"},{"key":"bibr3-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2009.07.005"},{"key":"bibr4-00912174211010529","first-page":"18","volume":"60","author":"Jurdi RA","year":"2005","journal-title":"Geriatrics"},{"key":"bibr5-00912174211010529","volume-title":"Textbook of consultation and liaison psychiatry","author":"Wise MG.","year":"2002","edition":"2"},{"key":"bibr6-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000612"},{"key":"bibr7-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050212"},{"key":"bibr8-00912174211010529","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.191376"},{"key":"bibr9-00912174211010529","first-page":"208","volume":"66","author":"Appleby BS","year":"2009","journal-title":"Arch Neurol"},{"key":"bibr10-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.12.2375"},{"key":"bibr11-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"bibr12-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004870"},{"key":"bibr13-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340190148022"},{"key":"bibr14-00912174211010529","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3241"},{"key":"bibr15-00912174211010529","unstructured":"Center for Disease Control. 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