{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:24:43Z","timestamp":1793215483159,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Project","award":["M-2022199"],"award-info":[{"award-number":["M-2022199"]}]},{"name":"Shandong Medical and Health Science and Technology Project","award":["202403090630"],"award-info":[{"award-number":["202403090630"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Psychiatry Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the antidepressant efficacy, cognitive impact, and safety profile of magnetic seizure therapy (MST) vs. modified electroconvulsive therapy (MECT) in Chinese adolescents with treatment-resistant major depressive disorder (MDD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center, evaluator-blinded, prospective randomized controlled trial enrolled 120 adolescents aged 13-18 years diagnosed with treatment-resistant MDD. Participants were randomly assigned to either the MST group or the MECT group (n = 60 per group). The primary outcome was improvement in depressive symptoms measured by the Beck Depression Inventory-II (BDI-II) score. Secondary outcomes included changes in cognitive function assessed by the Montreal Cognitive Assessment (MoCA), time to reorientation, and adverse event incidence per CTCAE 5.0 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The reduction of depressive symptoms on the BDI-II was significantly greater in the MECT group (51.8%) compared to the MST group (46.5%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), although clinical response rates were similar (90.0% vs 91.1%). The MST group showed significant improvement in MoCA total score, whereas the MECT group demonstrated a slight decline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). MST was associated with greater cognitive preservation (+0.96 vs 0.36 MoCA score), fewer adverse events (28.9% vs 64.0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and faster reorientation (6.9 \u00b1 1.8 min vs 18.7 \u00b1 6.8 min,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) compared to MECT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MST exhibited comparable antidepressant efficacy to MECT while offering superior cognitive protection and safety in adolescents with treatment-resistant MDD. These findings suggest MST may be a preferred treatment option balancing symptom relief with neurodevelopmental preservation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00912174251364987","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T18:04:43Z","timestamp":1754503483000},"page":"64-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cognitive preservation and antidepressant efficacy of magnetic seizure therapy in adolescents with treatment resistant major depressive disorder in China: A randomized controlled trial"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8245-0805","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Shandong Mental Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Shandong Mental Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-lin","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Shandong Mental Health Center, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-fang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Depressive Disorders (Section I), Shandong Mental Health Center, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_3_7_2_2","volume-title":"Adolescent Mental Health","author":"World Health Organization","unstructured":"World Health Organization. Adolescent Mental Health. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/adolescent-mental-health (Accessed 25 April 2024)."},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.009"},{"key":"e_1_3_7_4_2","volume-title":"Policy Statement on Electroconvulsive Therapy","author":"American Academy of Child and Adolescent Psychiatry","year":"2025","unstructured":"American Academy of Child and Adolescent Psychiatry. Policy Statement on Electroconvulsive Therapy; 2025. https:\/\/www.aacap.org\/aacap\/policy_statements\/2025\/ECT.aspx"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2000.10.269"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2011.0035"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.460"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/1\/016007"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","unstructured":"Deng Zhi-De Luber Bruce McClintock Shawn M et al. Clinical Outcomes of Magnetic Seizure Therapy vs Electroconvulsive Therapy for Major Depressive Episode: A Randomized Clinical Trial. JAMA Psychiatry; 2024:240-249. doi:10.1001\/jamapsychiatry.2023.459","DOI":"10.1001\/jamapsychiatry.2023.459"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05247yel"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2017.01.011"}],"container-title":["The International Journal of Psychiatry in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00912174251364987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00912174251364987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00912174251364987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:13:17Z","timestamp":1777457597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00912174251364987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/00912174251364987"],"URL":"https:\/\/doi.org\/10.1177\/00912174251364987","relation":{},"ISSN":["0091-2174","1541-3527"],"issn-type":[{"value":"0091-2174","type":"print"},{"value":"1541-3527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]}}}