{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:25:44Z","timestamp":1793039144278,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Psychiatry Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Despite excellent long-term survival, survivors often face an underrecognized psychosocial burden. This study examined how anxiety and depression relate to health-related quality of life (QoL) in DTC survivors, accounting for sociodemographic and clinical variables, to identify predictors of global health status and symptom burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this cross-sectional study, 518 biochemically stable DTC survivors (TSH 0.5-2.0\u00a0mIU\/L) attending routine follow-up at a tertiary nuclear medicine clinic completed the Hospital Anxiety and Depression Scale (HADS) and the European Organisation for Research and Treatment of Cancer QoL Questionnaire\u2013Core 30 (EORTC QLQ-C30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants (mean age 46.6 \u00b1 11.8\u00a0years; 86% female; mean time since diagnosis 6.8 \u00b1 4.6\u00a0years) showed high rates of depression (51%) and anxiety (26%). Women had higher anxiety\/depression and lower HRQoL than men. Those with depression had higher anxiety scores, lower global health\/functioning, and higher overall symptoms (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Anxiety showed broader, more consistent inverse associations with HRQoL than did depression. In multivariable linear regression, anxiety and depression were the strongest independent predictors of lower global health status and higher fatigue, whereas demographic (age, sex) and disease\/treatment variables (time since diagnosis, number of radioactive iodine treatments) were not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychological distress\u2014particularly anxiety\u2014was more strongly associated with poorer HRQoL than disease\/treatment indicators in DTC survivors. Routine psychosocial screening (eg, HADS), referral to psycho-oncology, targeted fatigue management, and gender-sensitive support should be integrated into endocrine follow-up to address this hidden survivor burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00912174251413349","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:52:58Z","timestamp":1767016378000},"page":"558-573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Anxiety, Depression, and Quality of Life Among Survivors of Differentiated Thyroid Cancer in T\u00fcrkiye"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1456-2499","authenticated-orcid":false,"given":"Hayriye Dilek","family":"Hamurcu","sequence":"first","affiliation":[{"name":"Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-2506","authenticated-orcid":false,"given":"Ahmet","family":"Kokurcan","sequence":"additional","affiliation":[{"name":"Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclin","family":"U\u00e7mak","sequence":"additional","affiliation":[{"name":"Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"\u00c7ayk\u00f6yl\u00fc","sequence":"additional","affiliation":[{"name":"Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Medical Faculty"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/10732748211029726"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40496"},{"key":"e_1_3_7_4_2","unstructured":"General Directorate of Public Health. T\u00fcrkiye cancer statistics 2019; 2023. https:\/\/hsgm.saglik.gov.tr\/tr\/kanser-istatistikleri. Accessed April 7 2025."},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2022.05.023"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0632"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08850-3"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-04035-4"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.5505\/kpd.2022.65983"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-023-00449-3"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","unstructured":"Tufekci D Ayaz T Sahin SB Hocaoglu C. The \u201cNon-Treated\u201d Versus \u201cLT3-Treated\u201d Protocols of Short-Term Hypothyroidism Induction in Differentiated Thyroid Cancer: An Analysis of Hypothyroid Complications Mood Disorders and Quality of Life. 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The reliability and validity of Turkish form of hospital anxiety and depression scale. 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Depressive disorders in cancer. In: Breitbart W, Butow P, Jacobsen P, Lam W, Lazenby M, Loscalzo M, eds. Psycho-Oncology. 3rd ed. New York: Oxford University Press; 2021:320-328.","edition":"3"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4095-3"},{"key":"e_1_3_7_28_2","volume-title":"T\u00fcrkiye Kanser \u0130statistikleri 2020","author":"Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Halk Sa\u011fl\u0131\u011f\u0131 T.C.","year":"2025","unstructured":"Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Halk Sa\u011fl\u0131\u011f\u0131 T.C. Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc (Kanser Dairesi Ba\u015fkanl\u0131\u011f\u0131). In: Birinci S, Demirkol ME, Bagci HH, eds. T\u00fcrkiye Kanser \u0130statistikleri 2020. (Republic of T\u00fcrkiye Ministry of Health, General Directorate of Public Health, Department of Cancer. Turkey Cancer Statistics 2020). Ankara: Republic of T\u00fcrkiye Ministry of Health, General Directorate of Public Health; 2025. https:\/\/hsgm.saglik.gov.tr\/depo\/birimler\/kanser-db\/Dokumanlar\/Istatistikler\/Turkiye_Kanser_Istatistikleri_2020.pdf"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"}],"container-title":["The International Journal of Psychiatry in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00912174251413349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00912174251413349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00912174251413349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:20:36Z","timestamp":1788963636000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00912174251413349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/00912174251413349"],"URL":"https:\/\/doi.org\/10.1177\/00912174251413349","relation":{},"ISSN":["0091-2174","1541-3527"],"issn-type":[{"value":"0091-2174","type":"print"},{"value":"1541-3527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]}}}