{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:15Z","timestamp":1792787655997,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The 2021 Clinical Capacity Enhancement Project of Jiangsu Province Hospital","award":["No. JSPH-NC-2021-7"],"award-info":[{"award-number":["No. JSPH-NC-2021-7"]}],"id":[{"id":"https:\/\/ror.org\/04py1g812","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Psychiatry Med"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of a combined psychological and functional exercise intervention on emotion, quality of life, and brain-derived neurotrophic factor (BDNF) levels in patients with Parkinson\u2019s disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized controlled trial, 172 patients with PD were randomly assigned into 2 groups with 86 patients in each group. The control group received routine care, while the intervention group received a 12-week intervention combining psychological support with functional exercise in addition to routine care. Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Parkinson\u2019s Disease Questionnaire-39 (PDQ-39), Barthel Index, Movement Disorder Society-Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS), and serum BDNF levels were assessed before and after the intervention. Adherence rates were also determined for each group. Spearman correlation was used to examine associations between changes in BDNF levels (\u0394BDNF) and changes in HAMA (\u0394HAMA) and HAMD (\u0394HAMD) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the end of the 12-week clinical trial, the intervention group demonstrated significantly lower HAMA, HAMD, PDQ-39, and MDS-UPDRS scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and higher Barthel Index scores and BDNF levels compared to the control group. The adherence rate in the intervention group was higher than in the control group (90.70% vs 76.74%, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A combined psychological and functional exercise intervention significantly improved emotional well-being, quality of life, daily functioning, treatment adherence, and BDNF levels (compared to the control group) in patients with PD. Based on these findings, this multi-component intervention may have value in treating PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00912174261422307","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:38:47Z","timestamp":1769708327000},"page":"799-812","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Combined Psychological and Functional Exercise Interventions on Emotion, Life Quality, and Brain-Derived Neurotrophic Factor Levels in Patients With Parkinson\u2019s Disease: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"61","author":[{"given":"Tao","family":"Ding","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6986-1955","authenticated-orcid":false,"given":"Huayu","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"issue":"10440","key":"e_1_3_5_2_2","first-page":"1988","volume":"403","author":"Department of Error","year":"2024","unstructured":"Department of Error. 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