{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:40:55Z","timestamp":1791380455470,"version":"4.3.3"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":4724,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>This randomized, double\u2010blind, placebo\u2010controlled study compared the time to onset of analgesia and the analgesic efficacy of two formulations of acetaminophen 1000 mg\u2014an effervescent solution and tablet\u2014in 242 patients with moderate or severe pain following dental surgery. Onset of analgesia was determined using a two\u2010stopwatch procedure. Analgesia was assessed over a 4\u2010hour period. Treatments were compared using standard indexes of pain intensity and pain relief and summary measures. Both acetaminophen formulations were significantly more effective than their corresponding placebo for all efficacy assessments. The median time to onset of analgesia was significantly shorter with effervescent acetaminophen (20 minutes) compared to tablet acetaminophen (45 minutes). During the first 45 minutes after administration, effervescent acetaminophen was significantly more effective at each scheduled assessment time than tablet acetaminophen. The median time to meaningful pain relief was significantly shorter with effervescent acetaminophen (45 minutes) compared to tablet acetaminophen (60 minutes). At 4 hours after administration, the pain relief was significantly better with tablet acetaminophen than with effervescent acetaminophen. No other significant differences were observed between the active treatments. In conclusion, effervescent acetaminophen produces a significantly faster onset of analgesia than tablet acetaminophen.<\/jats:p>","DOI":"10.1177\/00912700022009071","type":"journal-article","created":{"date-parts":[[2003,7,19]],"date-time":"2003-07-19T09:38:13Z","timestamp":1058607493000},"page":"370-378","source":"Crossref","is-referenced-by-count":42,"title":["Time to Onset of Analgesia and Analgesic Efficacy of Effervescent Acetaminophen 1000 mg Compared to Tablet Acetaminophen 1000 mg in Postoperative Dental Pain: A Single\u2010Dose, Double\u2010Blind, Randomized, Placebo\u2010Controlled Study"],"prefix":"10.1002","volume":"40","author":[{"given":"Philip L.","family":"M\u00f8ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven E.","family":"N\u00f8rholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9 E.","family":"Ganry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge H.","family":"Insuasty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise G.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse A.","family":"Skoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Sindet\u2010Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.1"},{"key":"e_1_2_1_3_2","first-page":"197","volume-title":"Paracetamol (Acetaminophen): A Critical Bibliographic Review","author":"Prescott LF","year":"1996"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.34015.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0149-2918(95)80063-8"},{"key":"e_1_2_1_6_2","first-page":"855","article-title":"Comparison of onset of analgesia of effervescent and non\u2010effervescent paracetamol based on calculation of rates of pain reduction (abstract)","volume":"36","author":"Ganry H","year":"1996","journal-title":"J Clin Pharmacol."},{"key":"e_1_2_1_7_2","first-page":"181","article-title":"Pharmacokinetics (PK) and pharmacodynamics (PD) of two acetaminophen (APAP) formulations in postsurgical dental pain (abstract)","volume":"49","author":"Sunshine A","year":"1991","journal-title":"Clin Pharmacol Ther."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018975919598"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/cpt1976202241","article-title":"A model to evaluate mild analgesics in oral surgery outpatients","volume":"20","author":"Cooper SA","year":"1976","journal-title":"Clin Pharmacol Ther."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03126-0"},{"key":"e_1_2_1_11_2","volume-title":"International Monitoring of Adverse Reactions to Drugs: Adverse Reaction Terminology","author":"WHO Collaborating Centre for International Drug Monitoring","year":"1997"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F00912700022009071","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/00912700022009071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T11:46:05Z","timestamp":1698579965000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/00912700022009071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1177\/00912700022009071"],"URL":"https:\/\/doi.org\/10.1177\/00912700022009071","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}