{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:50:18Z","timestamp":1761511818926},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":3719,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>Previous work has demonstrated that the chelation interaction seen with ciprofloxacin when it is coadministered with antacids also happens when it is coadministered with calcium\u2010fortified foods. This study was conducted to study whether this was a drug\u2010specific finding or whether the interaction occurs with other members of the fluoroquinolone class of drugs. Sixteen healthy volunteers received single 400\u2010mg oral doses of gatifloxacin with 12 ounces each of water, nonfortified orange juice, and calcium\u2010fortified orange juice and had plasma samples drawn for assay over the subsequent 48 hours. Results demonstrated significant increases in total oral clearance (15%) and volume of distribution (13%) along with a matching significant decrease (12%) in exposure (AUC) when gatifloxacin was taken with the fortified juice. Although not statistically significant, peak concentrations decreased by 15% and were reached (t<jats:sub>max<\/jats:sub>) approximately 38% later when gatifloxacin was coadministered with the calcium\u2010fortified juice. Bioavailability testing indicated that although the 90% confidence intervals (CIs) for the ratio of the geometric means of the calcium\u2010fortified juice and water arms' AUC stayed within the range of 80% to 125%, those for C<jats:sub>max<\/jats:sub> did not. This study demonstrated a chelation or adsorption interaction between the fortified juice and gatifloxacin that reached regulatory significance. As a result, clinicians may wish to instruct patients to take gatifloxacin either with nonfortified foods or on an empty stomach.<\/jats:p>","DOI":"10.1177\/0091270002239711","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T10:36:11Z","timestamp":1051526171000},"page":"92-96","source":"Crossref","is-referenced-by-count":12,"title":["Lack of Bioequivalence of Gatifloxacin When Coadministered with Calcium\u2010Fortified Orange Juice in Healthy Volunteers"],"prefix":"10.1002","volume":"43","author":[{"given":"Allison W.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Victory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy W.","family":"Amsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Food\u2010Effect Bioavailability and Fed Bioequivalence Studies: Study Design, Data Analysis, and Labeling","author":"Food and Drug Administration","year":"2001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.207"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb05526.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700222011364"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/00912700222011391"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.2.125"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.5.1073"},{"key":"e_1_2_5_9_2","unstructured":"Tequin\u2122 Product Information Bristol\u2010Myers Squibb April 2000."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.121152"},{"key":"e_1_2_5_11_2","first-page":"230","article-title":"Polymetholxylated flavones in orange juice are inhibitors of P\u2010glycoprotein but not cytochrome P450 3A4","volume":"293","author":"Takanaga H","year":"2000","journal-title":"J Pharmacol Exper Ther"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.3.1063"},{"key":"e_1_2_5_13_2","first-page":"955","article-title":"Transport of quinolone antibacterial drugs by human P\u2010glycoprotein expressed in a kidney epithelial cell line, LLC\u2010PK1","volume":"282","author":"Ito T","year":"1997","journal-title":"J Pharmacol Exper Ther"},{"key":"e_1_2_5_14_2","first-page":"360","article-title":"Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line Caco\u20102","volume":"295","author":"Yamaguchi H","year":"2000","journal-title":"J Pharmacol Exper Ther"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1128\/AAC.42.10.2607","article-title":"Secretion of sparfloxacin from the human intestinal Caco\u20102 cell line is altered by P\u2010glycoprotein inhibitors","volume":"42","author":"Cormet\u2010Boyaka E","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1067"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1177%2F0091270002239711","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0091270002239711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:20:35Z","timestamp":1697228435000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1177\/0091270002239711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1177\/0091270002239711"],"URL":"https:\/\/doi.org\/10.1177\/0091270002239711","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}