{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:21:23Z","timestamp":1760887283817},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":3660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>A randomized, double\u2010blind, within\u2010patient, crossover study was carried out after bilateral \u201cidentical\u201d surgical procedures using local anesthesia only. A 3\u2010day tablet regime of racemic ketoprofen 75 mg or acetaminophen 1000 mg qid (<jats:italic>x<\/jats:italic> 4) was given starting 3 hours after surgery. Ketoprofen reduced objectively measured swelling 27.8% (<jats:italic>p<\/jats:italic> &lt; 0.04) better than acetaminophen 3 days after surgery and 70.8% (<jats:italic>p<\/jats:italic> &lt; 0.02) better than acetaminophen 6 days after surgery. The pain intensity (PI) was lower after ketoprofen than after acetaminophen from 2 to 6 hours after the first drug intake (all <jats:italic>p<\/jats:italic>\u2010values = 0.03). Sum PI during the first (SUMPI<jats:sub><jats:italic>3.5\u20136<\/jats:italic><\/jats:sub>, <jats:italic>p<\/jats:italic> = 0.003) and second dose intervals (SUMPI<jats:sub><jats:italic>6.5\u20139<\/jats:italic><\/jats:sub>, <jats:italic>p<\/jats:italic> = 0.007) was lower for ketoprofen than for acetaminophen but not different for the third dose interval (SUMPI<jats:sub><jats:italic>9.5\u201311<\/jats:italic><\/jats:sub>, <jats:italic>p<\/jats:italic> = 0.53). Ketoprofen was a more effective analgesic than acetaminophen on the day of surgery (SUMPI<jats:sub><jats:italic>3.5\u201311<\/jats:italic><\/jats:sub>, <jats:italic>p<\/jats:italic> = 0.005). There was no difference (<jats:italic>p<\/jats:italic> &gt; 0.05) between the treatments with respect to mouth opening, drug preference, global evaluation, or adverse reports. Adverse reports included stomach pain and diarrhea in both treatment groups. Ketoprofen 75 mg <jats:italic>x<\/jats:italic> 4 for 3 days reduces subjectively assessed pain and objectively measured swelling (i.e., anti\u2010inflammatory effect) following third\u2010molar surgery.<\/jats:p>","DOI":"10.1177\/0091270002250603","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T10:30:40Z","timestamp":1051525840000},"page":"305-314","source":"Crossref","is-referenced-by-count":21,"title":["Ketoprofen 75 mg qid versus Acetaminophen 1000 mg qid for 3 Days on Swelling, Pain, and Other Postoperative Events after Third\u2010Molar Surgery"],"prefix":"10.1002","volume":"43","author":[{"given":"G. A.","family":"Bj\u00f8rnsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Haan\u00e6s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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